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Ionic Hydrogel for Accelerated Dopamine Delivery via Retrodialysis
(American Chemical Society, 2019-07-29)
Local drug delivery directly to the source of a given pathology using retrodialysis is a promising approach to treating otherwise untreatable diseases. As the primary material component in retrodialysis, the semipermeable ...
Elite Swimmers’ Training Patterns in the 25 Weeks Prior to Their Season’s Best Performances: Insights Into Periodization From a 20-Years Cohort
(Frontiers Media, 2019-04-10)
Background: This study investigated the periodization of elite swimmers' training over the 25 weeks preceding the major competition of the season.
Methods: We conducted a retrospective observational study of elite male ...
Training and Competition Readiness in Triathlon
(MDPI, 2019-04-29)
Triathlon is characterized by the multidisciplinary nature of the sport where swimming, cycling, and running are completed sequentially in different events, such as the sprint, Olympic, long-distance, and Ironman formats. ...
Raman imaging to quantify the thermal transformation degree of Pompeian yellow ochre caused by the 79 AD Mount Vesuvius eruption
(Springer, 2019-11-07)
Most of the wall paintings from Pompeii are decorated with red and yellow colors but the thermal impact of 79 AD MountVesuvius eruption promoted the partial transformation of some yellow-painted areas into red. The aim of ...
The Complex Phosphorylation Patterns That Regulate the Activity of Hsp70 and Its Cochaperones
(MDPI, 2019-08-23)
Proteins must fold into their native structure and maintain it during their lifespan to display the desired activity. To ensure proper folding and stability, and avoid generation of misfolded conformations that can be ...
Liver sinusoidal endothelial cell ICAM-1 mediated tumor/endothelial crosstalk drives the development of liver metastasis by initiating inflammatory and angiogenic responses
(Nature Publishing, 2019-09-11)
The prometastatic stroma generated through tumor cells/host cells interaction is critical for metastatic growth. To elucidate the role of ICAM-1 on the crosstalk between tumor and primary liver sinusoidal endothelial cells ...
Polyether Synthesis by Bulk Self-Condensation of Diols Catalyzed by Non-eutectic Acid Base Organocatalysts
(American Chemical Society, 2019-01-25)
Polyethers constitute a well-established class of polymers covering a wide range of applications from industrial man-ufacturing to nanomedicine. Nevertheless, their industrial implementation is limited to short chain ...
Association Between Medication Adherence and Oxidative Stress in Patients With First-Episode Mania
(Frontiers Media, 2019-03-26)
Poor adherence is a major problem in patients with manic episodes that impairs functionality and has unknown effects on oxidative stress. The objective of this study was to analyze the relationship between adherence to ...
Charge transport modulation in pseudorotaxane 1D stacks of acene and azaacene derivatives
(Royal Society of Chemistry, 2019-03-07)
Acenes have received a lot of attention because of their inherent and tunable absorbing, emissive, and charge transport properties for electronic, photovoltaic, and singlet fission applications, among others. Such properties ...
Functional Analysis of LDLR (Low-Density Lipoprotein Receptor) Variants in Patient Lymphocytes to Assess the Effect of Evinacumab in Homozygous Familial Hypercholesterolemia Patients With a Spectrum of LDLR Activity
(Lippincott Williams & Wilkins, 2019-10-03)
Objective: Homozygous familial hypercholesterolemia is a rare disease usually caused by LDLR (low-density lipoprotein receptor) mutations. Homozygous familial hypercholesterolemia is characterized by markedly elevated LDL-C ...