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Antioxidant defense system and family environment in adolescents with family history of psychosis
(BioMed Central, 2012-11-16)
[EN] Our objective was to determine antioxidant defence activity in healthy controls (HC) and healthy unaffected second-degree relatives of patients with early onset psychosis (HC-FHP),and to assess its relationship with ...
A neural extracellular matrix-based method for in vitro hippocampal neuron culture and dopaminergic differentiation of neural stem cells
(BioMed Central, 2013)
Background: The ability to recreate an optimal cellular microenvironment is critical to understand neuronal
behavior and functionality in vitro. An organized neural extracellular matrix (nECM) promotes neural cell ...
Association of Notch-1, osteopontin and stem-like cells in ENU-glioma malignant process
(Impact Journals LLC, 2018-07-31)
Notch-1 and osteopontin (OPN) mediate angiogenesis and glioma stem-like cell (GSLC) maintenance. However, the relationship between these molecules and GSLCs during the development of glioma is unknown. We investigate the ...
Isolation and characterization of myogenic precursor cells from human cremaster muscle
(Nature Publishing, 2019-03-05)
Human myogenic precursor cells have been isolated and expanded from a number of skeletal muscles, but alternative donor biopsy sites must be sought after in diseases where muscle damage is widespread. Biopsy sites must be ...
De la neurastenia a la enfermedad postesfuerzo: evolución de los criterios diagnósticos del síndrome de fatiga crónica/encefalomielitis miálgica
(Elsevier, 2019-06-08)
[ES] Presentamos la evolución de la terminología y los criterios diagnósticos para el síndrome de fatiga crónica/encefalomielitis miálgica.
Este síndrome es una entidad compleja y controvertida, de etiología desconocida, ...
Glyceryl trinitrate in first-episode psychosis unmedicated with antipsychotics: A randomised controlled pilot study
(Sage, 2020-08)
There is a pressing need for new classes of treatment for psychosis. A key therapeutic target for novel compounds is the NMDA receptor, which may be modulated by nitric oxide donors such as sodium nitroprusside (SNP). ...
Universal and selective interventions to promote good mental health in young people: Systematic review and meta-analysis
(Elsevier, 2020-12)
Promotion of good mental health in young people is important. Our aim was to evaluate the consistency and magnitude of the efficacy of universal/selective interventions to promote good mental health. A systematic ...
Increased physical activity is not enough to recover astrocytic population from dark-rearing. Synergy with multisensory enrichment is required
(Frontiers Research Foundation, 2013-10-04)
Elimination of sensory inputs (deprivation) modifies the properties of the sensory cortex and serves as a model for studying plasticity during postnatal development. Many studies on the effects of deprivation have been ...
CGP37157, an inhibitor of the mitochondrial Na+/Ca2+ exchanger, protects neurons from excitotoxicity by blocking voltage-gated Ca2+ channels
(Nature Publishing Group, 2014-04)
Inhibition of the mitochondrial Na+/Ca2+ exchanger (NCLX) by CGP37157 is protective in models of neuronal injury that involve disruption of intracellular Ca2+ homeostasis. However, the Ca2+ signaling pathways and stores ...
Sephin1 Protects Neurons against Excitotoxicity Independently of the Integrated Stress Response
(MDPI, 2020-08-24)
Sephin1 is a derivative of guanabenz that inhibits the dephosphorylation of the eukaryotic initiation factor 2 alpha (eIF2α) and therefore may enhance the integrated stress response (ISR), an adaptive mechanism against ...