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A Randomized Controlled Trial Protocol to Test The Efficacy of a Dual-TaskMulticomponent Exercise Program in the Attenuation of Frailty in Long-Term Nursing Home Residents: Aging-ONDUAL-TASK Study
(Springer Nature, 2019-01-08)
BACKGROUND: The purpose of the Aging-ONDUAL-TASK study is to determine if a supervised dual-task program carried out in long-term nursing homes is able to attenuate frailty in a greater extent than the same multicomponent ...
Regulation of boar sperm functionality by the nitric oxidesynthase/nitric oxide system
(Springer, 2019-08)
Purpose Nitric oxide (NO) is a free radical synthesized mainly by nitric oxide synthases (NOSs). NO regulates many aspects in sperm physiology in different species. However, in vitro studies investigating NOS distribution, ...
Manipulation of bicarbonate concentration in sperm capacitation media improves in vitro fertilisation output in porcine species
(Biomed Central, 2019-03-11)
BackgroundThe in vivo concentration of bicarbonate (HCO3-), one of the essential sperm capacitating effectors, varies greatly in the different environments sperm go through from cauda epididymis to the fertilisation site. ...
Videoconference-Based Physical Performance Tests: Reliability and Feasibility Study
(MDPI, 2022)
Validated tools to evaluate physical performance remotely with real-time supervision are lacking. We assessed test–retest and inter-rater reliability, as well as the feasibility of carrying out the five-repetition sit-to-stand ...
Metabolic adaptations in spontaneously immortalized PGC-1α knock-out mouse embryonic fibroblasts increase their oncogenic potential
(Elsevier, 2020-01)
PGC-1 alpha controls, to a large extent, the capacity of cells to respond to changing nutritional requirements and energetic demands. The key role of metabolic reprogramming in tumor development has highlighted the potential ...
Effects of COVID-19 Lockdown on Physical Activity and Health-Related Quality of Life in Older Adults Who Regularly Exercise
(MDPI, 2021)
The aim of the study was to analyze the effect of social distancing on physical activity (PA) and Health-Related Quality of Life (HRQoL) in active Spanish older adults according to their physical functionality. The study ...
Serum Sestrin-1 Concentration Is Higher in Frail than Non-Frail Older People Living in Nursing Homes
(MDPI, 2022-01-19)
Given the increasing prevalence of frailty and its implications for public health, the identification of biomarkers to detect frailty is essential. Sestrin-1 is a protein with a protective role in muscle function. This ...
Impact of COVID-19 Confinement on Physical Activity and Sedentary Behaviour in Spanish University Students: Role of Gender
(MDPI, 2021-01-06)
During the COVID-19 pandemic, entire populations were instructed to live in home-confinement to prevent the expansion of the disease. Spain was one of the countries with the strictest conditions, as outdoor physical activity ...
Evidence of Paraoxonases 1, 2, and 3 Expression in Human Ovarian Granulosa Cells
(MDPI, 2021-08-22)
Increasing evidence suggests that the antioxidant paraoxonase proteins, PON1, PON2, and PON3, have a role in reproduction and may be synthesized by ovarian cells. The aim of this work was to investigate whether human ovarian ...
Screening of Natural Stilbene Oligomers from Vitis vinifera for Anticancer Activity on Human Hepatocellular Carcinoma Cells
(MDPI, 2020-06-01)
The characterization of bioactive resveratrol oligomers extracted from Vitis vinifera canes has been recently reported. Here, we screened six of these compounds (ampelopsin A, trans-ε-viniferin, hopeaphenol, isohopeaphenol, ...