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Co-administration of Anti microRNA-124 and -137 Oligonucleotides Prevents Hippocampal Neural Stem Cell Loss Upon Non-convulsive Seizures
(Frontiers Media, 2019-02-19)
Convulsive seizures promote adult hippocampal neurogenesis (AHN) through a transient activation of neural stem/progenitor cells (NSPCs) in the subgranular zone (SGZ) of the dentate gyrus (DG). However, in a significant ...
Development and Maintenance of the Brain’s Immune Toolkit: Microglia and Non-Parenchymal Brain Macrophages
(Wiley, 2018-06)
Microglia and non-parenchymal macrophages located in the perivascular space, the meninges and the choroid plexus are independent immune populations that play vital roles in brain development, homeostasis, and tissue healing. ...
The C Terminus of the Ribosomal-Associated Protein LrtA Is an Intrinsically Disordered Oligomer
(MDPI, 2018-12-05)
The 191-residue-long LrtA protein of Synechocystis sp. PCC 6803 is involved in post-stress survival and in stabilizing 70S ribosomal particles. It belongs to the hibernating promoting factor (HPF) family, intervening in ...
Metabolic Effects of Oral Phenelzine Treatment on High-Sucrose-Drinking Mice
(MDPI, 2018-10)
Phenelzine has been suggested to have an antiobesity effect by inhibiting de novo lipogenesis, which led us to investigate the metabolic effects of oral chronic phenelzine treatment in high-sucrose-drinking mice. ...
Existence of Solutions for a System of Integral Equations Using a Generalization of Darbo’s Fixed Point Theorem
(MDPI, 2020-04-01)
In this paper, an extension of Darbo’s fixed point theorem via θ -F-contractions in a Banach space has been presented. Measure of noncompactness approach is the main tool in the presentation of our proofs. As an application, ...
Quantum cosmology of the Big Rip: Within GR and in a modified theory of gravity
(MDPI, 2017-04-14)
Quantum gravity is the theory that is expected to successfully describe systems that are under strong gravitational effects while at the same time being of an extreme quantum nature. When this principle is applied to the ...
D5 dopamine receptors control glutamatergic AMPA transmission between the motor cortex and subthalamic nucleus
(Nature Publishing, 2018-06-11)
Corticofugal fibers target the subthalamic nucleus (STN), a component nucleus of the basal ganglia, in addition to the striatum, their main input. The cortico-subthalamic, or hyperdirect, pathway, is thought to supplement ...
In-Depth Proteomic Characterization of Classical and Non-Classical Monocyte Subsets
(MDPI, 2018-02-05)
Monocytes are bone marrow-derived leukocytes that are part of the innate immune system. Monocytes are divided into three subsets: classical, intermediate and non-classical, which can be differentiated by their expression ...
Multi-Response Optimization of WEDM Process Parameters for Machining of Superelastic Nitinol Shape-Memory Alloy Using a Heat-Transfer Search Algorithm
(MDPI, 2019-04-18)
Nitinol, a shape-memory alloy (SMA), is gaining popularity for use in various applications. Machining of these SMAs poses a challenge during conventional machining. Henceforth, in the current study, the wire-electric ...
Effects of a physical activity programme to prevent physical performance decline in onco-geriatric patients: a randomized multicentre trial
(Wiley, 2019-04)
Background Older adults with cancer experience negative long-term functional effects of both cancer and treatments. Exercise may minimize their age-related and cancer-related functional decline. Methods We conducted a ...