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dc.contributor.authorAbulí, Anna
dc.contributor.authorCastells, Antoni
dc.contributor.authorBujanda Fernández de Pierola, Luis
dc.contributor.authorLozano, Juan José
dc.contributor.authorBessa, Xavier
dc.contributor.authorHernández, Cristina
dc.contributor.authorÁlvarez-Urturi, Cristina
dc.contributor.authorPellisé, María
dc.contributor.authorEsteban-Jurado, Clara
dc.contributor.authorHijona Muruamendiaraz, Elizabeth
dc.contributor.authorBurón, Andrea
dc.contributor.authorMacià, Francesc
dc.contributor.authorGrau, Jaume
dc.contributor.authorGuayta, Rafael
dc.contributor.authorCastellví-Bel, Sergi
dc.contributor.authorAndreu, Montserrat
dc.contributor.authorPROCOLON research group
dc.date.accessioned2018-02-05T14:22:19Z
dc.date.available2018-02-05T14:22:19Z
dc.date.issued2016-04-14
dc.identifier.citationPLOS ONE 11(4) : (2016) // Article ID e0153084es_ES
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/10810/24828
dc.description.abstractBackground Common low-penetrance genetic variants have been consistently associated with colorectal cancer risk. Aim To determine if these genetic variants are associated also with adenoma susceptibility and may improve selection of patients with increased risk for advanced adenomas and/or multiplicity (>= 3 adenomas). Methods We selected 1,326 patients with increased risk for advanced adenomas and/or multiplicity and 1,252 controls with normal colonoscopy from population-based colorectal cancer screening programs. We conducted a case-control association study analyzing 30 colorectal cancer susceptibility variants in order to investigate the contribution of these variants to the development of subsequent advanced neoplasia and/or multiplicity. Results We found that 14 of the analyzed genetic variants showed a statistically significant association with advanced adenomas and/or multiplicity: the probability of developing these lesions increased with the number of risk alleles reaching a 2.3-fold risk increment in individuals with >= 17 risk alleles. Conclusions Nearly half of the genetic variants associated with colorectal cancer risk are also related to advanced adenoma and/or multiplicity predisposition. Assessing the number of risk alleles in individuals within colorectal cancer screening programs may help to identify better a subgroup with increased risk for advanced neoplasia and/or multiplicity in the general population.es_ES
dc.description.sponsorshipThis work was supported by grants from: Instituto de Salud Carlos III-FEDER (RD09/0076/00036), the Xarxa de Bancs de tumors sponsored by Pla Director d'Oncologia de Catalunya (XBTC), Fondo de Investigacion Sanitaria/FEDER (PI10/00918, PI11/00219, PI14/00173, PI14/00441), Ministerio de Economia y Competitividad (SAF2010-19273), Asociacion Espanola contra el Cancer (Fundacion Cientifica GCB13131592CAST), and COST Action BM1206 (SCB). SCB is supported by a contract from the Fondo de Investigacion Sanitaria (CP 03-0070) and Agencia de Gestio d'Ajuts Universitaris i de Recerca (Generalitat de Catalunya, 2014SGR255, 2014SGR135). CIBERehd is funded by the Instituto de Salud Carlos III.es_ES
dc.language.isoenges_ES
dc.publisherPUBLIC LIBRARY SCIENCEes_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectgenome -wide associationes_ES
dc.subjectAmerican-Cancer Societyes_ES
dc.subjecttask-forcees_ES
dc.subjectriskes_ES
dc.subjectlocies_ES
dc.subjectmetaanalysises_ES
dc.subjectpopulationes_ES
dc.subjectpolypses_ES
dc.subjectsurveillancees_ES
dc.subjectpolypectomyes_ES
dc.titleGenetic Variants Associated with Colorectal Adenoma Susceptibilityes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.holder© 2016 Abulí et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.es_ES
dc.rights.holderAtribución 3.0 España
dc.relation.publisherversionhttp://journals.plos.org/plosone/article?id=10.1371/journal.pone.0153084es_ES
dc.identifier.doi10.1371/journal.pone.0153084
dc.departamentoesMedicinaes_ES
dc.departamentoeuMedikuntzaes_ES


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© 2016 Abulí et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Except where otherwise noted, this item's license is described as © 2016 Abulí et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.