Genetic Variants Associated with Colorectal Adenoma Susceptibility

Abulí, Anna; Castells, Antoni; Bujanda Fernández de Pierola, Luis; Lozano, Juan José; Bessa, Xavier; Hernández, Cristina; Álvarez-Urturi, Cristina; Pellisé, María; Esteban-Jurado, Clara; Hijona Muruamendiaraz, Elizabeth; Burón, Andrea; Macià, Francesc; Grau, Jaume; Guayta, Rafael; Castellví-Bel, Sergi; Andreu, Montserrat; PROCOLON research group

dc.contributor.author	Abulí, Anna
dc.contributor.author	Castells, Antoni
dc.contributor.author	Bujanda Fernández de Pierola, Luis
dc.contributor.author	Lozano, Juan José
dc.contributor.author	Bessa, Xavier
dc.contributor.author	Hernández, Cristina
dc.contributor.author	Álvarez-Urturi, Cristina
dc.contributor.author	Pellisé, María
dc.contributor.author	Esteban-Jurado, Clara
dc.contributor.author	Hijona Muruamendiaraz, Elizabeth
dc.contributor.author	Burón, Andrea
dc.contributor.author	Macià, Francesc
dc.contributor.author	Grau, Jaume
dc.contributor.author	Guayta, Rafael
dc.contributor.author	Castellví-Bel, Sergi
dc.contributor.author	Andreu, Montserrat
dc.contributor.author	PROCOLON research group
dc.date.accessioned	2018-02-05T14:22:19Z
dc.date.available	2018-02-05T14:22:19Z
dc.date.issued	2016-04-14
dc.identifier.citation	PLOS ONE 11(4) : (2016) // Article ID e0153084	es_ES
dc.identifier.issn	1932-6203
dc.identifier.uri	http://hdl.handle.net/10810/24828
dc.description.abstract	Background Common low-penetrance genetic variants have been consistently associated with colorectal cancer risk. Aim To determine if these genetic variants are associated also with adenoma susceptibility and may improve selection of patients with increased risk for advanced adenomas and/or multiplicity (>= 3 adenomas). Methods We selected 1,326 patients with increased risk for advanced adenomas and/or multiplicity and 1,252 controls with normal colonoscopy from population-based colorectal cancer screening programs. We conducted a case-control association study analyzing 30 colorectal cancer susceptibility variants in order to investigate the contribution of these variants to the development of subsequent advanced neoplasia and/or multiplicity. Results We found that 14 of the analyzed genetic variants showed a statistically significant association with advanced adenomas and/or multiplicity: the probability of developing these lesions increased with the number of risk alleles reaching a 2.3-fold risk increment in individuals with >= 17 risk alleles. Conclusions Nearly half of the genetic variants associated with colorectal cancer risk are also related to advanced adenoma and/or multiplicity predisposition. Assessing the number of risk alleles in individuals within colorectal cancer screening programs may help to identify better a subgroup with increased risk for advanced neoplasia and/or multiplicity in the general population.	es_ES
dc.description.sponsorship	This work was supported by grants from: Instituto de Salud Carlos III-FEDER (RD09/0076/00036), the Xarxa de Bancs de tumors sponsored by Pla Director d'Oncologia de Catalunya (XBTC), Fondo de Investigacion Sanitaria/FEDER (PI10/00918, PI11/00219, PI14/00173, PI14/00441), Ministerio de Economia y Competitividad (SAF2010-19273), Asociacion Espanola contra el Cancer (Fundacion Cientifica GCB13131592CAST), and COST Action BM1206 (SCB). SCB is supported by a contract from the Fondo de Investigacion Sanitaria (CP 03-0070) and Agencia de Gestio d'Ajuts Universitaris i de Recerca (Generalitat de Catalunya, 2014SGR255, 2014SGR135). CIBERehd is funded by the Instituto de Salud Carlos III.	es_ES
dc.language.iso	eng	es_ES
dc.publisher	PUBLIC LIBRARY SCIENCE	es_ES
dc.rights	info:eu-repo/semantics/openAccess	es_ES
dc.rights.uri	http://creativecommons.org/licenses/by/3.0/es/	*
dc.subject	genome -wide association	es_ES
dc.subject	American-Cancer Society	es_ES
dc.subject	task-force	es_ES
dc.subject	risk	es_ES
dc.subject	loci	es_ES
dc.subject	metaanalysis	es_ES
dc.subject	population	es_ES
dc.subject	polyps	es_ES
dc.subject	surveillance	es_ES
dc.subject	polypectomy	es_ES
dc.title	Genetic Variants Associated with Colorectal Adenoma Susceptibility	es_ES
dc.type	info:eu-repo/semantics/article	es_ES
dc.rights.holder	© 2016 Abulí et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.	es_ES
dc.rights.holder	Atribución 3.0 España
dc.relation.publisherversion	http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0153084	es_ES
dc.identifier.doi	10.1371/journal.pone.0153084
dc.departamentoes	Medicina	es_ES
dc.departamentoeu	Medikuntza	es_ES

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© 2016 Abulí et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Except where otherwise noted, this item's license is described as © 2016 Abulí et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.