Genetic Variants Associated with Colorectal Adenoma Susceptibility
dc.contributor.author | Abulí, Anna | |
dc.contributor.author | Castells, Antoni | |
dc.contributor.author | Bujanda Fernández de Pierola, Luis | |
dc.contributor.author | Lozano, Juan José | |
dc.contributor.author | Bessa, Xavier | |
dc.contributor.author | Hernández, Cristina | |
dc.contributor.author | Álvarez-Urturi, Cristina | |
dc.contributor.author | Pellisé, María | |
dc.contributor.author | Esteban-Jurado, Clara | |
dc.contributor.author | Hijona Muruamendiaraz, Elizabeth | |
dc.contributor.author | Burón, Andrea | |
dc.contributor.author | Macià, Francesc | |
dc.contributor.author | Grau, Jaume | |
dc.contributor.author | Guayta, Rafael | |
dc.contributor.author | Castellví-Bel, Sergi | |
dc.contributor.author | Andreu, Montserrat | |
dc.contributor.author | PROCOLON research group | |
dc.date.accessioned | 2018-02-05T14:22:19Z | |
dc.date.available | 2018-02-05T14:22:19Z | |
dc.date.issued | 2016-04-14 | |
dc.identifier.citation | PLOS ONE 11(4) : (2016) // Article ID e0153084 | es_ES |
dc.identifier.issn | 1932-6203 | |
dc.identifier.uri | http://hdl.handle.net/10810/24828 | |
dc.description.abstract | Background Common low-penetrance genetic variants have been consistently associated with colorectal cancer risk. Aim To determine if these genetic variants are associated also with adenoma susceptibility and may improve selection of patients with increased risk for advanced adenomas and/or multiplicity (>= 3 adenomas). Methods We selected 1,326 patients with increased risk for advanced adenomas and/or multiplicity and 1,252 controls with normal colonoscopy from population-based colorectal cancer screening programs. We conducted a case-control association study analyzing 30 colorectal cancer susceptibility variants in order to investigate the contribution of these variants to the development of subsequent advanced neoplasia and/or multiplicity. Results We found that 14 of the analyzed genetic variants showed a statistically significant association with advanced adenomas and/or multiplicity: the probability of developing these lesions increased with the number of risk alleles reaching a 2.3-fold risk increment in individuals with >= 17 risk alleles. Conclusions Nearly half of the genetic variants associated with colorectal cancer risk are also related to advanced adenoma and/or multiplicity predisposition. Assessing the number of risk alleles in individuals within colorectal cancer screening programs may help to identify better a subgroup with increased risk for advanced neoplasia and/or multiplicity in the general population. | es_ES |
dc.description.sponsorship | This work was supported by grants from: Instituto de Salud Carlos III-FEDER (RD09/0076/00036), the Xarxa de Bancs de tumors sponsored by Pla Director d'Oncologia de Catalunya (XBTC), Fondo de Investigacion Sanitaria/FEDER (PI10/00918, PI11/00219, PI14/00173, PI14/00441), Ministerio de Economia y Competitividad (SAF2010-19273), Asociacion Espanola contra el Cancer (Fundacion Cientifica GCB13131592CAST), and COST Action BM1206 (SCB). SCB is supported by a contract from the Fondo de Investigacion Sanitaria (CP 03-0070) and Agencia de Gestio d'Ajuts Universitaris i de Recerca (Generalitat de Catalunya, 2014SGR255, 2014SGR135). CIBERehd is funded by the Instituto de Salud Carlos III. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | PUBLIC LIBRARY SCIENCE | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | genome -wide association | es_ES |
dc.subject | American-Cancer Society | es_ES |
dc.subject | task-force | es_ES |
dc.subject | risk | es_ES |
dc.subject | loci | es_ES |
dc.subject | metaanalysis | es_ES |
dc.subject | population | es_ES |
dc.subject | polyps | es_ES |
dc.subject | surveillance | es_ES |
dc.subject | polypectomy | es_ES |
dc.title | Genetic Variants Associated with Colorectal Adenoma Susceptibility | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | © 2016 Abulí et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | es_ES |
dc.rights.holder | Atribución 3.0 España | |
dc.relation.publisherversion | http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0153084 | es_ES |
dc.identifier.doi | 10.1371/journal.pone.0153084 | |
dc.departamentoes | Medicina | es_ES |
dc.departamentoeu | Medikuntza | es_ES |
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Except where otherwise noted, this item's license is described as © 2016 Abulí et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.