Infective endocarditis in hypertrophic cardiomyopathy A multicenter, prospective, cohort study
dc.contributor.author | Dominguez, Fernando | |
dc.contributor.author | Ramos, Antonio | |
dc.contributor.author | Bouza, Emilio | |
dc.contributor.author | Muñoz, Patricia | |
dc.contributor.author | Valerio, Maricela C. | |
dc.contributor.author | Fariñas, Carmen | |
dc.contributor.author | De Berrazueta, José Ramón | |
dc.contributor.author | Zarauza, Jesús | |
dc.contributor.author | Pericás Pulido, Juan Manuel | |
dc.contributor.author | Paré, Juan Carlos | |
dc.contributor.author | De Alarcón, Arístides | |
dc.contributor.author | Sousa, Dolores | |
dc.contributor.author | Rodriguez Bailón, Isabel | |
dc.contributor.author | Montejo Baranda, José Miguel | |
dc.contributor.author | Noureddine, Mariam | |
dc.contributor.author | García Vázquez, Elisa | |
dc.contributor.author | Garcia-Pavia, Pablo | |
dc.date.accessioned | 2018-02-14T15:57:44Z | |
dc.date.available | 2018-02-14T15:57:44Z | |
dc.date.issued | 2016-06 | |
dc.identifier.citation | Medicine 95(26) : (2016) // Article ID e4008 | es_ES |
dc.identifier.issn | 0025-7974 | |
dc.identifier.issn | 1536-5964 | |
dc.identifier.uri | http://hdl.handle.net/10810/25056 | |
dc.description.abstract | Infective endocarditis (IE) complicating hypertrophic cardiomyopathy (HCM) is a poorly known entity. Although current guidelines do not recommend IE antibiotic prophylaxis (IEAP) in HCM, controversy remains.This study sought to describe the clinical course of a large series of IE HCM and to compare IE in HCM patients with IE patients with and without an indication for IEAP.Data from the GAMES IE registry involving 27 Spanish hospitals were analyzed. From January 2008 to December 2013, 2000 consecutive IE patients were prospectively included in the registry. Eleven IE HCM additional cases from before 2008 were also studied. Clinical, microbiological, and echocardiographic characteristics were analyzed in IE HCM patients (n = 34) and in IE HCM reported in literature (n = 84). Patients with nondevice IE (n = 1807) were classified into 3 groups: group 1, HCM with native-valve IE (n = 26); group 2, patients with IEAP indication (n = 696); group 3, patients with no IEAP indication (n = 1085). IE episode and 1-year follow-up data were gathered.One-year mortality in IE HCM was 42% in our study and 22% in the literature. IE was more frequent, although not exclusive, in obstructive HCM (59% and 74%, respectively). Group 1 exhibited more IE predisposing factors than groups 2 and 3 (62% vs 40% vs 50%, P<0.01), and more previous dental procedures (23% vs 6% vs 8%, P<0.01). Furthermore, Group 1 experienced a higher incidence of Streptococcus infections than Group 2 (39% vs 22%, P<0.01) and similar to Group 3 (39% vs 30%, P = 0.34). Overall mortality was similar among groups (42% vs 36% vs 35%, P = 0.64).IE occurs in HCM patients with and without obstruction. Mortality of IE HCM is high but similar to patients with and without IEAP indication. Predisposing factors, previous dental procedures, and streptococcal infection are higher in IE HCM, suggesting that HCM patients could benefit from IEAP. | es_ES |
dc.description.sponsorship | This work was supported in part by grant RD12/0042/0066 by the Plan Estatal de I+D+I 2013-2016 funded by the ISCIII European Regional Development Fund (FEDER) "A way of making Europe". | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Lippincott Williams & Wilkins | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-sa/3.0/es/ | * |
dc.subject | antibiotic prophylaxis | es_ES |
dc.subject | endocarditis | es_ES |
dc.subject | hypertrophic cardiomyopathy | es_ES |
dc.subject | bacterial-endocarditis | es_ES |
dc.subject | prophylaxis | es_ES |
dc.subject | prevention | es_ES |
dc.subject | diagnaosis | es_ES |
dc.subject | recommendations | es_ES |
dc.subject | guidelines | es_ES |
dc.title | Infective endocarditis in hypertrophic cardiomyopathy A multicenter, prospective, cohort study | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | Copyright © 2016 the Author(s). Published by Wolters Kluwer Health, Inc. All rights reserved. This is an open access article distributed under the Creative Commons Attribution-ShareAlike License 4.0, which allows others to remix, tweak, and build upon the work, even for commercial purposes, as long as the author is credited and the new creations are licensed under the identical terms. | es_ES |
dc.rights.holder | Atribución-CompartirIgual 3.0 España | * |
dc.relation.publisherversion | https://journals.lww.com/md-journal/fulltext/2016/06280/Infective_endocarditis_in_hypertrophic.40.aspx | es_ES |
dc.identifier.doi | 10.1097/MD.0000000000004008 | |
dc.departamentoes | Medicina | es_ES |
dc.departamentoeu | Medikuntza | es_ES |
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Except where otherwise noted, this item's license is described as Copyright © 2016 the Author(s). Published by Wolters Kluwer Health, Inc. All rights reserved.
This is an open access article distributed under the Creative Commons Attribution-ShareAlike License 4.0, which allows others to remix, tweak, and build upon the
work, even for commercial purposes, as long as the author is credited and the new creations are licensed under the identical terms.