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dc.contributor.authorGarcía-Álvarez, Lara
dc.contributor.authorSanz, María Mercedes
dc.contributor.authorMarín, Mercedes
dc.contributor.authorFariñas, Carmen
dc.contributor.authorMontejo Baranda, José Miguel
dc.contributor.authorGoikoetxea Agirre, Ane Josune
dc.contributor.authorRodríguez García, Raquel
dc.contributor.authorDe Alarcón, Arístides
dc.contributor.authorAlmela, Manuel
dc.contributor.authorFernández-Hidalgo, Núria
dc.contributor.authorAlonso Socas, María del Mar
dc.contributor.authorGoenaga, Miguel Ángel
dc.contributor.authorNavas, Enrique
dc.contributor.authorVicioso, Luis
dc.contributor.authorOteo, José Antonio
dc.date.accessioned2018-03-28T09:10:56Z
dc.date.available2018-03-28T09:10:56Z
dc.date.issued2016-06
dc.identifier.citationMedicine 95(26) : (2016) // Article ID e4058es_ES
dc.identifier.issn0025-7974
dc.identifier.issn1536-5964
dc.identifier.urihttp://hdl.handle.net/10810/26034
dc.description.abstractTropheryma whipplei endocarditis is an uncommon condition with very few series and <90 cases reported in the literature. The aim of the study was to analyze the epidemiological, clinical, and outcome characteristics of 17 cases of T. whipplei endocarditis recruited in our country from a multicentric cohort from 25 Spanish hospitals from the Spanish Collaboration on EndocarditisGrupo de Apoyo al Manejo de la Endocarditis infecciosa en Espana.From a total of 3165 cases included in the cohort, 14.2% were diagnosed of blood culture negative endocarditis (BCNE) and 3.5% of these had T. whipplei endocarditis. This condition was more frequent in men. The average age was 60.3 years. Previous cardiac condition was present in 35.3% of the cases. The main clinical manifestation was cardiac failure (76.5%) while fever was only present in the 35.3%. Ecocardiography showed vegetations in 64.7% of patients. Surgery was performed in all but 1 cases and it allowed the diagnosis when molecular assays were performed. A broad range rRNA 16S polymerase chain reaction was used for first instance in all laboratories and different specific targets for T. whipplei were employed for confirmation. A concomitant Whipple disease was diagnosed in 11.9% of patients. All patients received specific antimicrobial treatment for at least 1 year, with no relapse and complete recovery.T. whipplei endocarditis is an uncommon condition with an atypical presentation that must be considered in the diagnosis of BCNE. The prognosis is very good when an appropriate surgical management and antimicrobial-specific treatment is given.es_ES
dc.language.isoenges_ES
dc.publisherLippincott Williams & Wilkinses_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectblood culture negative endocarditises_ES
dc.subjectinfectious endocarditises_ES
dc.subjectTes_ES
dc.subjectwhipplei endocarditises_ES
dc.subjecttropheryma whippleies_ES
dc.subjecttrimethoprimes_ES
dc.subjectceftriaxonees_ES
dc.titleTropheryma whipplei endocarditis in Spain Case: reports of 17 prospective caseses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.holderCopyright © 2016 the Author(s). Published by Wolters Kluwer Health, Inc. All rights reserved. This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.es_ES
dc.rights.holderAtribución 3.0 España*
dc.relation.publisherversionhttps://journals.lww.com/md-journal/Fulltext/2016/06280/Tropheryma_whipplei_endocarditis_in_Spain__Case.68.aspxes_ES
dc.identifier.doi10.1097/MD.0000000000004058
dc.departamentoesMedicinaes_ES
dc.departamentoeuMedikuntzaes_ES


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Copyright © 2016 the Author(s). Published by Wolters Kluwer Health, Inc. All rights reserved.
This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Except where otherwise noted, this item's license is described as Copyright © 2016 the Author(s). Published by Wolters Kluwer Health, Inc. All rights reserved. This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.