Palladium-Catalyzed Dehydrogenative Coupling: An Efficient Synthetic Strategy for the Construction of the Quinoline Core
dc.contributor.author | Carral Menoyo, Asier | |
dc.contributor.author | Ortiz de Elguea Flecha, Verónica | |
dc.contributor.author | Martínez Nunes, Mikel | |
dc.contributor.author | Sotomayor Anduiza, María Nuria | |
dc.contributor.author | Lete Expósito, María Esther | |
dc.date.accessioned | 2018-04-09T08:49:40Z | |
dc.date.available | 2018-04-09T08:49:40Z | |
dc.date.issued | 2017-09 | |
dc.identifier.citation | Marine Drugs 15(9) : (2017) // Article ID 276 | es_ES |
dc.identifier.issn | 1660-3397 | |
dc.identifier.uri | http://hdl.handle.net/10810/26168 | |
dc.description.abstract | Palladium-catalyzed dehydrogenative coupling is an efficient synthetic strategy for the construction of quinoline scaffolds, a privileged structure and prevalent motif in many natural and biologically active products, in particular in marine alkaloids. Thus, quinolines and 1,2-dihydroquinolines can be selectively obtained in moderate-to-good yields via intramolecular C-H alkenylation reactions, by choosing the reaction conditions. This methodology provides a direct method for the construction of this type of quinoline through an efficient and atom economical procedure, and constitutes significant advance over the existing procedures that require preactivated reaction partners. | es_ES |
dc.description.sponsorship | Ministerio de Economia y Competitividad (CTQ2013-41229-P, CTQ2016-74881-P), Gobierno Vasco (IT1045-16) and Universidad del Pais Vasco/Euskal Herriko Unibertsitatea UPV/EHU are gratefully acknowledged for their financial support. V.O.-d.-E., A.C.-M. wish to thank Gobierno Vasco for grants. Technical and human support provided by Servicios Generales de Investigacion SGIker (UPV/EHU, MINECO, GV/EJ, ERDF and ESF) is also acknowledged. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/CTQ2013-41229-P | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/CTQ2016-74881-P | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | quinoline | es_ES |
dc.subject | synthesis | es_ES |
dc.subject | palladium | es_ES |
dc.subject | coupling | es_ES |
dc.subject | C-H alkenylation | es_ES |
dc.subject | marine natural-products | es_ES |
dc.subject | C-H functionalization | es_ES |
dc.subject | pyridoacridine alkalloids | es_ES |
dc.subject | bond functionalization | es_ES |
dc.subject | indole-derivatives | es_ES |
dc.subject | alkenylation | es_ES |
dc.subject | heterocycles | es_ES |
dc.subject | olefination | es_ES |
dc.subject | cyclization | es_ES |
dc.subject | selectivity | es_ES |
dc.title | Palladium-Catalyzed Dehydrogenative Coupling: An Efficient Synthetic Strategy for the Construction of the Quinoline Core | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | es_ES |
dc.rights.holder | Atribución 3.0 España | * |
dc.relation.publisherversion | http://www.mdpi.com/1660-3397/15/9/276 | es_ES |
dc.identifier.doi | 10.3390/md15090276 | |
dc.departamentoes | Química orgánica II | es_ES |
dc.departamentoeu | Kimika organikoa II | es_ES |
Files in this item
This item appears in the following Collection(s)
Except where otherwise noted, this item's license is described as © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access
article distributed under the terms and conditions of the Creative Commons Attribution
(CC BY) license (http://creativecommons.org/licenses/by/4.0/).