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The Influence of Copolymer Composition on PLGA/nHA Scaffolds’ Cytotoxicity and In Vitro Degradation

dc.contributor.authorDíaz Tajada, Esperanza
dc.contributor.authorPuerto Lecanda, Igor ORCID
dc.contributor.authorRibeiro, Sylvie
dc.contributor.authorLanceros Méndez, Senentxu
dc.contributor.authorBarandiarán García, José Manuel
dc.date.accessioned2018-04-13T12:16:54Z
dc.date.available2018-04-13T12:16:54Z
dc.date.issued2017-07-06
dc.identifier.citationNanomaterials 7(7) : (2016) // Article ID 173es_ES
dc.identifier.issn2079-4991
dc.identifier.urihttp://hdl.handle.net/10810/26280
dc.description.abstractThe influence of copolymer composition on Poly(Lactide-co-Glycolide)/nanohydroxyapatite (PLGA/nHA) composite scaffolds is studied in the context of bone tissue engineering and regenerative medicine. The composite scaffolds are fabricated by thermally-induced phase separation and the effect of bioactive nanoparticles on their in vitro degradation in phosphate-buffered solution at 37 degrees C is analyzed over eight weeks. The indirect cytotoxicity evaluation of the samples followed an adaptation of the ISO 10993-5 standard test method. Based on the measurement of their molecular weight, molar mass, pH, water absorption and dimensions, the porous scaffolds of PLGA with a lower lactide/glycolide (LA/GA) molar ratio degraded faster due to their higher hydrophilicity. All of the samples without and with HA are not cytotoxic, demonstrating their potential for tissue engineering applications.es_ES
dc.description.sponsorshipTechnical and human support provided by SGIker (UPV/EHU, MICINN, GV/EJ, ERDF and ESF) is really appreciated. This work was supported by the Portuguese Foundation for Science and Technology (FCT) in the framework of the Strategic Funding UID/FIS/04650/2013 and Grant SFRH/BD/111478/2015 (S.R). The authors acknowledge funding by the Spanish Ministry of Economy and Competitiveness (MINECO) through the project MAT2016-76039-C4-3-R (Agencia Estatal de Investigacion(AEI)/FEDER, Union Europea(UE)).es_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.relationinfo:eu-repo/grantAgreement/MINECO/MAT2016-76039-C4-3-Res_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectscaffoldses_ES
dc.subjectPLGAes_ES
dc.subjectnHAes_ES
dc.subjectcytotoxicityes_ES
dc.subjectin vitro degradationes_ES
dc.subjecthydrolytic degradationes_ES
dc.subjectregenerative medicinees_ES
dc.subjectporous scaffoldses_ES
dc.subjecthydroxyapatitees_ES
dc.subjectbiomaterialses_ES
dc.titleThe Influence of Copolymer Composition on PLGA/nHA Scaffolds’ Cytotoxicity and In Vitro Degradationes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.holderThis is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).es_ES
dc.rights.holderAtribución 3.0 España*
dc.relation.publisherversionhttp://www.mdpi.com/2079-4991/7/7/173es_ES
dc.identifier.doi10.3390/nano7070173
dc.departamentoesIngeniería Minera y Metalúrgica y Ciencia de los Materialeses_ES
dc.departamentoeuMeatze eta metalurgia ingeniaritza materialen zientziaes_ES


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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
Except where otherwise noted, this item's license is described as This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).