Cellulose Nanocrystal Membranes as Excipients for Drug Delivery Systems
dc.contributor.author | Barbosa, Ananda M. | |
dc.contributor.author | Robles Barrios, José Eduardo | |
dc.contributor.author | Ribeiro, Juliana S. | |
dc.contributor.author | Lund, Rafael G. | |
dc.contributor.author | Carreno, Neftali L.V. | |
dc.contributor.author | Labidi Bouchrika, Jalel | |
dc.date.accessioned | 2018-05-24T17:18:06Z | |
dc.date.available | 2018-05-24T17:18:06Z | |
dc.date.issued | 2016-12-12 | |
dc.identifier.citation | Materials 9(12) : (2016) // Article ID 1002 | es_ES |
dc.identifier.issn | 1996-1944 | |
dc.identifier.uri | http://hdl.handle.net/10810/27084 | |
dc.description.abstract | In this work, cellulose nanocrystals (CNCs) were obtained from flax fibers by an acid hydrolysis assisted by sonochemistry in order to reduce reaction times. The cavitation inducted during hydrolysis resulted in CNC with uniform shapes, and thus further pretreatments into the cellulose are not required. The obtained CNC exhibited a homogeneous morphology and high crystallinity, as well as typical values for surface charge. Additionally, CNC membranes were developed from CNC solution to evaluation as a drug delivery system by the incorporation of a model drug. The drug delivery studies were carried out using chlorhexidine (CHX) as a drug and the antimicrobial efficiency of the CNC membrane loaded with CHX was examined against Gram-positive bacteria Staphylococcus aureus (S. Aureus). The release of CHX from the CNC membranes is determined by UV-Vis. The obtaining methodology of the membranes proved to be simple, and these early studies showed a potential use in antibiotic drug delivery systems due to the release kinetics and the satisfactory antimicrobial activity. | es_ES |
dc.description.sponsorship | The authors would like to acknowledge the Department of Education, Universities and Investigation of the Basque Government (project IT1008-16), the Federal Agency for Support and Evaluation of Graduate Education (CAPES) through process BEX 8710/14-7, the Mexican Council of Science and Technology (CONACyT) through scholarship 216178 and theBrazilian National Council for Scientific and Technological Development for financial support through CNPq (# 482251/2013-1) for financially supporting this work. The authors also thank Maite Insausti and Oihane Arriortua for their kind help and support with Nanosizer and SGIker of the University of the Basque Country UPV/EHU for technical and human support provided with XRD, NMR and AFM characterizations and Altair Faes of the Regional Center of Oncology of the Federal University of Pelotas (UFPel) for the use of the equipment Eldorado 78. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | cellulose nanocrystals | es_ES |
dc.subject | chlorhexidine | es_ES |
dc.subject | staphylococcus aureus | es_ES |
dc.title | Cellulose Nanocrystal Membranes as Excipients for Drug Delivery Systems | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). | es_ES |
dc.rights.holder | Atribución 3.0 España | * |
dc.relation.publisherversion | http://www.mdpi.com/1996-1944/9/12/1002 | es_ES |
dc.identifier.doi | 10.3390/ma9121002 | |
dc.departamentoes | Ingeniería química y del medio ambiente | es_ES |
dc.departamentoeu | Ingeniaritza kimikoa eta ingurumenaren ingeniaritza | es_ES |
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Except where otherwise noted, this item's license is described as © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).