Estimation of preterm labor immediacy by nonlinear methods
dc.contributor.author | Malaina Celada, Iker | |
dc.contributor.author | Martínez Fernández, Luis | |
dc.contributor.author | Matorras Weinig, José Roberto | |
dc.contributor.author | Bringas Roldán, Carlos | |
dc.contributor.author | Aranburu Laka, Larraitz | |
dc.contributor.author | Fernández-Llebrez del Rey, Luis | |
dc.contributor.author | González, Leire | |
dc.contributor.author | Arana, Itziar | |
dc.contributor.author | Pérez Pinilla, Martín Blas | |
dc.contributor.author | Martínez de la Fuente Martínez, Ildefonso Abel | |
dc.date.accessioned | 2018-06-13T10:13:04Z | |
dc.date.available | 2018-06-13T10:13:04Z | |
dc.date.issued | 2017-06-01 | |
dc.identifier.citation | PLOS ONE 12(6) : (2017) // Article ID e0178257 | es_ES |
dc.identifier.issn | 1932-6203 | |
dc.identifier.uri | http://hdl.handle.net/10810/27506 | |
dc.description.abstract | Preterm delivery affects about one tenth of human births and is associated with an increased perinatal morbimortality as well as with remarkable costs. Even if there are a number of predictors and markers of preterm delivery, none of them has a high accuracy. In order to find quantitative indicators of the immediacy of labor, 142 cardiotocographies (CTG) recorded from women consulting because of suspected threatened premature delivery with gestational ages comprehended between 24 and 35 weeks were collected and analyzed. These 142 samples were divided into two groups: the delayed labor group (n = 75), formed by the women who delivered more than seven days after the tocography was performed, and the anticipated labor group (n = 67), which corresponded to the women whose labor took place during the seven days following the recording. As a means of finding significant differences between the two groups, some key informational properties were analyzed by applying nonlinear techniques on the tocography recordings. Both the regularity and the persistence levels of the delayed labor group, which were measured by Approximate Entropy (ApEn) and Generalized Hurst Exponent (GHE) respectively, were found to be significantly different from the anticipated labor group. As delivery approached, the values of ApEn tended to increase while the values of GHE tended to decrease, suggesting that these two methods are sensitive to labor immediacy. On this paper, for the first time, we have been able to estimate childbirth immediacy by applying nonlinear methods on tocographies. We propose the use of the techniques herein described as new quantitative diagnosis tools for premature birth that significantly improve the current protocols for preterm labor prediction worldwide. | es_ES |
dc.description.sponsorship | Work by the first author was supported by the Basque Government grant PRE-2015-1-194,and work by the first and second authors by the Basque Government grant IT974-16. This work was also supported in part by FERRING laboratories Madrid, Spain (RM), https://www.ferring.com/en/home/. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Public Library Science | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | approximate entropy | es_ES |
dc.subject | time-series | es_ES |
dc.subject | delivery | es_ES |
dc.subject | risk | es_ES |
dc.subject | prediction | es_ES |
dc.subject | regularity | es_ES |
dc.subject | birth | es_ES |
dc.subject | heart | es_ES |
dc.subject | motions | es_ES |
dc.subject | uterus | es_ES |
dc.title | Estimation of preterm labor immediacy by nonlinear methods | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | 2017 Malaina et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | es_ES |
dc.rights.holder | Atribución 3.0 España | * |
dc.relation.publisherversion | http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0178257 | es_ES |
dc.identifier.doi | 10.1371/journal.pone.0178257 | |
dc.departamentoes | Biología celular e histología | es_ES |
dc.departamentoes | Especialidades médico-quirúrgicas | es_ES |
dc.departamentoes | Matemática aplicada | es_ES |
dc.departamentoes | Matemáticas | es_ES |
dc.departamentoeu | Biologia zelularra eta morfologia zientziak | es_ES |
dc.departamentoeu | Matematika | es_ES |
dc.departamentoeu | Matematika aplikatua | es_ES |
dc.departamentoeu | Medikuntza eta kirurgia espezialitateak | es_ES |
dc.departamentoeu | Zelulen biologia eta histologia | es_ES |
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Except where otherwise noted, this item's license is described as 2017 Malaina et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.