dc.contributor.author | Kljajevica, Vanja | |
dc.contributor.author | Erramuzpe Aliaga, Asier | |
dc.date.accessioned | 2018-06-25T10:09:39Z | |
dc.date.available | 2018-06-25T10:09:39Z | |
dc.date.issued | 2018-02 | |
dc.identifier.citation | Brain And Cognition 120 : 26-33 (2018) | es_ES |
dc.identifier.issn | 0278-2626 | |
dc.identifier.issn | 1090-2147 | |
dc.identifier.uri | http://hdl.handle.net/10810/27708 | |
dc.description.abstract | There is currently little understanding on whether retrieval of proper names differs in midlife compared to young adulthood and if so, whether the age differences in this ability are associated with differences in structural integrity of the cerebral cortex. To answer these questions, we studied retrieval of proper names in 115 cognitively healthy middle-aged persons (49.7, +/- 3.2), comparing their performance on a tip-of-the-tongue (TOT) task with that of 68 young persons (25.4, +/- 3.5) from the Cam-Can data repository (http://www.mrc-cbu.cam.ac.uk/datasets/camcan/). Grey matter (GM) density and cortical thickness were used as indices of structural integrity of the cerebral cortex. The middle-aged (MA) group experienced more TOTs during proper names retrieval than young adults (YA), (t = 3.789, p < .005) and had considerably less GM density and cortical thickness across a range of brain areas bilaterally. Small clusters in left BA 45 and right BA 44 (cortical thickness) and in right BA 40 (volumetry) revealed group differences when accounting for TOTs. However, we observed no correlations between MA's TOT scores and GM volumes or cortical thickness of the brain regions typically reported as implicated in retrieval of proper names: left anterior temporal lobe, left insula, and left superior and middle temporal gyri. | es_ES |
dc.description.sponsorship | Data collection and sharing for this project was provided by the Cambridge Centre for Ageing and Neuroscience (CamCAN). CamCAN funding was provided by the UK Biotechnology and Biological Sciences Research Council (grant number BB/H008217/1), together with support from the UK Medical Research Council and University of Cambridge, UK. Preparation of the present work was partially supported by a grant from IKERBASQUE, Basque Foundation for Science (111407EMDD) to V.K. and Basque Government grant (PRE/2014/1/252) to A.M. We are grateful to Jesus Cortes for supervising pre-processing of cortical thickness data and to three anonymous reviewers, whose careful comments led to major improvements of the manuscript. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | * |
dc.subject | proper names | es_ES |
dc.subject | tip-of-the-tongue states | es_ES |
dc.subject | aging | es_ES |
dc.subject | voxel-based morphometry | es_ES |
dc.subject | grey matter density | es_ES |
dc.subject | cortical thickness | es_ES |
dc.subject | white-matter integrity | es_ES |
dc.subject | surface-based analysis | es_ES |
dc.subject | word-finding failures | es_ES |
dc.subject | of-the-tongue | es_ES |
dc.subject | alzheimers-disease | es_ES |
dc.subject | gray-matter | es_ES |
dc.subject | human brain | es_ES |
dc.subject | cognitive decline | es_ES |
dc.subject | peoples names | es_ES |
dc.title | Proper Name Retrieval And Structural Integrity Of Cerebral Cortex In Midlife: A Cross-Sectional Study | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/). | es_ES |
dc.rights.holder | Atribución-NoComercial-SinDerivadas 3.0 España | * |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S0278262617301434?via%3Dihub | es_ES |
dc.identifier.doi | 10.1016/j.bandc.2017.11.003 | |
dc.departamentoes | Biología celular e histología | es_ES |
dc.departamentoeu | Biologia zelularra eta morfologia zientziak | es_ES |