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dc.contributor.authorEtxaniz Iriondo, Asier
dc.contributor.authorGonzález Bullón, David
dc.contributor.authorMartín Plágaro, César Augusto
dc.contributor.authorOstolaza Echabe, Elena Amaya
dc.date.accessioned2018-11-09T14:08:17Z
dc.date.available2018-11-09T14:08:17Z
dc.date.issued2018-06-09
dc.identifier.citationToxins 10 : (2018) // Article ID 234es_ES
dc.identifier.issn2072-6651
dc.identifier.urihttp://hdl.handle.net/10810/29598
dc.description.abstractPermeabilization of the plasma membrane represents an important threat for any cell, since it compromises its viability by disrupting cell homeostasis. Numerous pathogenic bacteria produce pore-forming toxins that break plasma membrane integrity and cause cell death by colloid-osmotic lysis. Eukaryotic cells, in turn, have developed different ways to cope with the effects of such membrane piercing. Here, we provide a short overview of the general mechanisms currently proposed for plasma membrane repair, focusing more specifically on the cellular responses to membrane permeabilization by pore-forming toxins and presenting new data on the effects and cellular responses to the permeabilization by an RTX (repeats in toxin) toxin, the adenylate cyclase toxin-hemolysin secreted by the whooping cough bacterium Bordetella pertussis, which we have studied in the laboratory.es_ES
dc.description.sponsorshipThis study was supported by grants from the Basque Government (Grupos Consolidados IT849-13) and grant from the Spanish Ministerio de Economia y Competitividad (BFU2017-82758-PAEI/FEDER, UE).es_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.relationinfo:eu-repo/grantAgreement/MINECO/(BFU2017-82758-PAEI/FEDER)es_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectmembrane permeabilizationes_ES
dc.subjectmembrane repaires_ES
dc.subjectpore-forming toxinses_ES
dc.subjectRTX toxinses_ES
dc.subjectadenylate cyclase toxines_ES
dc.subjectplasma-membranees_ES
dc.subjectbordetella-pertussises_ES
dc.subjectcell-membranees_ES
dc.subjectescherichia-colies_ES
dc.subjectvibrio-choleraees_ES
dc.subjectstreptolysin-oes_ES
dc.subjectalpha-toxines_ES
dc.subjectstaphylococcus-aureuses_ES
dc.subjectexocytosises_ES
dc.titleMembrane Repair Mechanisms against Permeabilization by Pore-Forming Toxinses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.holder© 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). You are free to: Share — copy and redistribute the material in any medium or format Adapt — remix, transform, and build upon the material for any purpose, even commercially.es_ES
dc.rights.holderAtribución 3.0 España*
dc.relation.publisherversionhttps://www.mdpi.com/2072-6651/10/6/234es_ES
dc.identifier.doi10.3390/toxins10060234
dc.departamentoesBioquímica y biología moleculares_ES
dc.departamentoeuBiokimika eta biologia molekularraes_ES


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© 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access
article distributed under the terms and conditions of the Creative Commons Attribution
(CC BY) license (http://creativecommons.org/licenses/by/4.0/).
You are free to: Share — copy and redistribute the material in any medium or format
Adapt — remix, transform, and build upon the material for any purpose, even commercially.
Except where otherwise noted, this item's license is described as © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). You are free to: Share — copy and redistribute the material in any medium or format Adapt — remix, transform, and build upon the material for any purpose, even commercially.