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dc.contributor.authorValcárcel Jiménez, Lorea
dc.contributor.authorMacchia, Alice
dc.contributor.authorMartín Martín, Natalia
dc.contributor.authorCortazar, Ana Rosa
dc.contributor.authorSchaub Clerigué, Ariane
dc.contributor.authorPujana Vaquerizo, Mikel
dc.contributor.authorFernández Ruiz, Sonia
dc.contributor.authorLacasa Viscasillas, Isabel
dc.contributor.authorSantos Martín, Aida
dc.contributor.authorLoizaga Iriarte, Ana
dc.contributor.authorUnda Urzaiz, Jesús Miguel
dc.contributor.authorHermanova, Ivana
dc.contributor.authorAstobiza Pérez, Janire
dc.contributor.authorGraupera, Mariona
dc.contributor.authorJulia, Starkova
dc.contributor.authorSutherland, James
dc.contributor.authorBarrio Olano, María Rosa
dc.contributor.authorAransay Bañares, Ana María
dc.contributor.authorCarracedo Pérez, Arkaitz
dc.contributor.authorTorrano Moya, Verónica
dc.date.accessioned2018-12-14T09:42:22Z
dc.date.available2018-12-14T09:42:22Z
dc.date.issued2018-10-11
dc.identifier.citationCell Death & Disease 9 : (2018) // Article ID 1041es_ES
dc.identifier.issn2041-4889
dc.identifier.urihttp://hdl.handle.net/10810/30345
dc.description.abstractThe dysregulation of gene expression is an enabling hallmark of cancer. Computational analysis of transcriptomics data from human cancer specimens, complemented with exhaustive clinical annotation, provides an opportunity to identify core regulators of the tumorigenic process. Here we exploit well-annotated clinical datasets of prostate cancer for the discovery of transcriptional regulators relevant to prostate cancer. Following this rationale, we identify Microphthalmia-associated transcription factor (MITF) as a prostate tumor suppressor among a subset of transcription factors. Importantly, we further interrogate transcriptomics and clinical data to refine MITF perturbation-based empirical assays and unveil Crystallin Alpha B (CRYAB) as an unprecedented direct target of the transcription factor that is, at least in part, responsible for its tumor-suppressive activity in prostate cancer. This evidence was supported by the enhanced prognostic potential of a signature based on the concomitant alteration of MITF and CRYAB in prostate cancer patients. In sum, our study provides proof-of-concept evidence of the potential of the bioinformatics screen of publicly available cancer patient databases as discovery platforms, and demonstrates that the MITF-CRYAB axis controls prostate cancer biology.es_ES
dc.description.sponsorshipThe work of V. Torrano is funded by Fundacion Vasca de Innovacion e Investigacion Sanitarias, BIOEF (BIO15/CA/052), the AECC J.P. Bizkaia and the Basque Department of Health (2016111109). The work of A. Carracedo is supported by the Basque Department of Industry, Tourism and Trade (Etortek) and the Department of Education (IKERTALDE IT1106-16, also participated by A. Gomez-Munoz), the BBVA Foundation, the MINECO (SAF2016-79381-R (FEDER/EU); Severo Ochoa Excellence Accreditation SEV-2016-0644; Excellence Networks SAF2016-81975-REDT), European Training Networks Project (H2020-MSCA-ITN-308 2016 721532), the AECC IDEAS16 (IDEAS175CARR) and the European Research Council (Starting Grant 336343, PoC 754627). CIBERONC was co-funded with FEDER funds. The work of M. Graupera is supported by the MINECO (SAF2014-59950-P). The work of A. Aransay is supported by the Basque Department of Industry, Tourism and Trade (Etortek and Elkartek Programs), the Innovation Technology Department of Bizkaia County, CIBERehd Network and Spanish MINECO the Severo Ochoa Excellence Accreditation (SEV-2016-0644). R. Barrio acknowledges Spanish MINECO (BFU2014-52282-P, Consolider BFU2014-57703-REDC), the Departments of Education and Industry of the Basque Government (PI2012/42) and the Bizkaia County. J. Starkova acknowledges the Ministry of Health of Czech Republic AZV NV15-28848A. We are thankful to the Basque Biobank for Research (BIOEF) for the custody and management of human prostate specimens used in this study.es_ES
dc.language.isoenges_ES
dc.publisherNature Publishing Groupes_ES
dc.relationinfo:eu-repo/grantAgreement/MINECO/SAF2016-79381-Res_ES
dc.relationinfo:eu-repo/grantAgreement/MINECO/SEV-2016-0644es_ES
dc.relationinfo:eu-repo/grantAgreement/MINECO/BFU2014-52282-Pes_ES
dc.relationinfo:eu-repo/grantAgreement/MINECO/BFU2014-57703-REDCes_ES
dc.relationinfo:eu-repo/grantAgreement/MINECO/SAF2016-81975-REDTes_ES
dc.relationinfo:eu-repo/grantAgreement/MINECO/SAF2014-59950-Pes_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectalpha-B-crystallines_ES
dc.subjectbreast-canceres_ES
dc.subjectmalignant-melanomaes_ES
dc.subjectcolorectal-canceres_ES
dc.subjectinduced apoptosises_ES
dc.subjectprogressiones_ES
dc.subjectexpressiones_ES
dc.subjectcellses_ES
dc.subjectPGC1-alphaes_ES
dc.subjectproliferationes_ES
dc.titleIntegrative Analysis of Transcriptomics and Clinical Data Uncovers the Tumor- Suppressive Activity of MITF in Prostate Canceres_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.holderOpen Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.es_ES
dc.rights.holderAtribución 3.0 España*
dc.relation.publisherversionhttps://www.nature.com/articles/s41419-018-1096-6es_ES
dc.identifier.doi10.1038/s41419-018-1096-6
dc.departamentoesBioquímica y biología moleculares_ES
dc.departamentoesCirugía, radiología y medicina físicaes_ES
dc.departamentoeuBiokimika eta biologia molekularraes_ES
dc.departamentoeuKirurgia,erradiologia eta medikuntza fisikoaes_ES


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Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Except where otherwise noted, this item's license is described as Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.