Acetylome in Human Fibroblasts From Parkinson's Disease Patients
dc.contributor.author | Yakhine Diop, Sokhna M. S. | |
dc.contributor.author | Rodríguez Arribas, Mario | |
dc.contributor.author | Martínez Chacón, Guadalupe | |
dc.contributor.author | Uribe Carretero, Elisabet | |
dc.contributor.author | Gómez Sánchez, Rubén | |
dc.contributor.author | Aiastui, Ana | |
dc.contributor.author | López de Munain Arregui, Adolfo José | |
dc.contributor.author | Bravo San Pedro, José M. | |
dc.contributor.author | Niso Santano, Mireia | |
dc.contributor.author | González Polo, Rosa A. | |
dc.contributor.author | Fuentes Rodríguez, José Manuel | |
dc.date.accessioned | 2018-12-14T09:46:25Z | |
dc.date.available | 2018-12-14T09:46:25Z | |
dc.date.issued | 2018-04-17 | |
dc.identifier.citation | Frontiers In Cellular Neuroscience 12 : (2018) // Article ID 97 | es_ES |
dc.identifier.issn | 1662-5102 | |
dc.identifier.uri | http://hdl.handle.net/10810/30349 | |
dc.description.abstract | Parkinson's disease (PD) is amultifactorial neurodegenerative disorder. The pathogenesis of this disease is associated with gene and environmental factors. Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most frequent genetic cause of familial and sporadic PD. Moreover, posttranslational modifications, including protein acetylation, are involved in the molecular mechanism of PD. Acetylation of lysine proteins is a dynamic process that ismodulated in PD. In this descriptive study, we characterized the acetylated proteins and peptides in primary fibroblasts from idiopathic PD (IPD) and genetic PD harboring G2019S or R1441G LRRK2 mutations. Identified acetylated peptides are modulated between individuals' groups. Although acetylated nuclear proteins are the most represented in cells, they are hypoacetylated in IPD. Results display that the level of hyperacetylated and hypoacetylated peptides are, respectively, enhanced in genetic PD and in IPD cells. | es_ES |
dc.description.sponsorship | We are grateful to the patients and donors without which these work would not have been possible. The authors thank M. P. Delgado-Luceno. The proteomic analysis was performed in the Proteomics Facility of UCM that belongs to ProteoRed, PRB2-ISCIII, supported by grant PT13/0001. SY-D was supported by Isabel Gemio Foundation. EU-C was supported by a FPU predoctoral fellowship (FPU16/00684) from Ministerio de Educacion, Cultura y Deporte, Spain. RG-S was supported by a Marie Sklodowska-Curie Individual Fellowship (IF-EF) (655027) from the European Commission. JB-S was funded by La Ligue Contre le Cancer. MN-S was supported by Contrato Ramon y Cajal (RYC-2016-20883) from Ministerio de Economia y Competitividad, Spain. MR-A was supported by a FPU predoctoral fellowship (FPU13/01237) from Ministerio de Educacion, Cultura y Deporte, Spain. JF received research support from the Instituto de Salud Carlos III, CIBERNED (CB06/05/004) and Instituto de Salud Carlos III, FIS (PI15/00034). RG-P was supported by a Contrato destinado a la retencion y atraccion del talento investigador, TA13009 from Junta de Extremadura, as well as research support from the Instituto de Salud Carlos III, FIS (PI14/00170). This work was also supported by Fondo Europeo de Desarrollo Regional (FEDER) from the European Union. The authors also thank FUNDESALUD for helpful assistance. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Frontiers Media SA | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/RYC-2016-20883 | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | acetylation | es_ES |
dc.subject | LRRK2 | es_ES |
dc.subject | peptides | es_ES |
dc.subject | parkinson | es_ES |
dc.subject | proteins | es_ES |
dc.subject | serotonergic dysfunction | es_ES |
dc.subject | histone acetylation | es_ES |
dc.subject | tubulin acetylation | es_ES |
dc.subject | autophagy | es_ES |
dc.subject | acetyltransferase | es_ES |
dc.subject | hyperacetylation | es_ES |
dc.subject | ubiquitin | es_ES |
dc.subject | kinase | es_ES |
dc.title | Acetylome in Human Fibroblasts From Parkinson's Disease Patients | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | Copyright © 2018 Yakhine-Diop, Rodríguez-Arribas, Martínez-Chacón, Uribe-Carretero, Gómez-Sánchez, Aiastui, López de Munain, Bravo-San Pedro, Niso-Santano, González-Polo and Fuentes. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | es_ES |
dc.rights.holder | Atribución 3.0 España | * |
dc.relation.publisherversion | https://www.frontiersin.org/articles/10.3389/fncel.2018.00097/full | es_ES |
dc.identifier.doi | 10.3389/fncel.2018.00097 | |
dc.departamentoes | Neurociencias | es_ES |
dc.departamentoeu | Neurozientziak | es_ES |
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Except where otherwise noted, this item's license is described as Copyright © 2018 Yakhine-Diop, Rodríguez-Arribas, Martínez-Chacón, Uribe-Carretero, Gómez-Sánchez, Aiastui, López de Munain, Bravo-San Pedro, Niso-Santano, González-Polo and Fuentes. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.