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dc.contributor.authorMosqueda Solís, Andrea
dc.contributor.authorSánchez, Juana
dc.contributor.authorReynés, Bárbara
dc.contributor.authorPortillo Baquedano, María Puy
dc.contributor.authorPalou, Andreu
dc.contributor.authorPicó, Catalina
dc.identifier.citationScientific Reports 8 : (2018) // Article ID 15100es_ES
dc.description.abstractWe aimed to assess the potential effects of hesperidin and capsaicin, independently and in combination, to prevent the development of obesity and its related metabolic alterations in rats fed an obesogenic diet. Three-month-old male Wistar rats were divided into 5 groups: Control (animals fed a standard diet), WD (animals fed a high fat/sucrose (western) diet), HESP (animals fed a western diet + hesperidin (100 mg/kg/day)), CAP (animals fed a western diet + capsaicin (4 mg/kg/day)), and HESP + CAP (animals fed a western diet + hesperidin (100 mg/kg/day) + capsaicin (4 mg/kg/day)). Hesperidin and capsaicin were administered by gavage. Capsaicin decreased body fat gain and prevented insulin resistance, whereas hesperidin showed little effect on body fat gain and no apparent effects on insulin resistance. No additive effects were observed with the combination. Capsaicin and hesperidin, separately, improved blood lipid profile, diminished hepatic lipid accumulation, and prevented non-alcoholic steatohepatitis in western diet-fed rats, but the combination showed lower effects. Hesperidin alone, and to a lesser extent capsaicin or the combination, displayed hypotensive effects in western diet-fed rats. In conclusion, capsaicin and hesperidin, separately, exhibit health beneficial effects on metabolic syndrome-related alterations in western diet-fed rats, but the effects are mitigated with the combination.es_ES
dc.description.sponsorshipThis work was supported by the Spanish Government (AGL2015-67019-P), and the Instituto de Salud Carlos III, Centro de Investigacion Biomedica en Red Fisiopatologia de la Obesidad y Nutricion, CIBERobn. Laboratory of Molecular Biology, Nutrition and Biotechnology is a member of the European Research Network of Excellence NuGO (The European Nutrigenomics Organization, EU Contract: no. FP6-506360). A. Mosqueda-Solis is a recipient of a doctoral fellowship from the CONACYT (Mexico).es_ES
dc.publisherNature Publishing Groupes_ES
dc.subjectspontaneously hypertensive-ratses_ES
dc.subjectfatty liver-diseasees_ES
dc.subjectglucosyl hesperidines_ES
dc.subjectpungent principlees_ES
dc.subjectcapsicum fruitses_ES
dc.titleHesperidin and Capsaicin, But Not The Combination, Prevent Hepatic Steatosis and Other Metabolic Syndrome-Related Alterations in Western Diet-Fed Ratses_ES
dc.rights.holderAtribución 3.0 España*
dc.departamentoesFarmacia y ciencias de los alimentoses_ES
dc.departamentoeuFarmazia eta elikagaien zientziakes_ES

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