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dc.contributor.authorRueda-Alaña, Eneritz
dc.contributor.authorMartínez-Garay, Isabel
dc.contributor.authorEncinas Pérez, Juan Manuel
dc.contributor.authorMolnár, Zoltán
dc.contributor.authorGarcía-Moreno, Fernando
dc.date.accessioned2019-01-17T13:03:46Z
dc.date.available2019-01-17T13:03:46Z
dc.date.issued2018-10-31
dc.identifier.citationFrontiers in Neuroscience 12 : (2018) // Article ID 792es_ES
dc.identifier.issn1662-453X
dc.identifier.urihttp://hdl.handle.net/10810/30938
dc.description.abstractThe neocortex (NCx) generates at the dorsal region of the pallium in the forebrain. Several adjacent structures also contribute with neurons to NCx. Ventral pallium (VP) is considered to generate several populations of neurons that arrive through tangential migration to the NCx. Amongst them are the Cajal-Retzius cells and some transient pyramidal neurons. However, the specific site and timing of generation, trajectory of migration and actual contribution to the pyramidal population remains elusive. Here, we investigate the spatio-temporal origin of neuronal populations from VP in an in vivo model, using a transposase mediated in utero electroporation method in embryonic mouse. From E11 to E14 cells born at the lateral corner of the neocortical neuroepithelium including the VP migrated ventro-laterally to settle all areas of the ventral telencephalon. Specifically, neurons migrated into amygdala (Ag), olfactory cortices, and claustrum (Cl). However, we found no evidence for any neurons migrating tangentially toward the NCx, regardless the antero-posterior level and developmental time of the electroporation. Our results challenge the described ventral-pallial origin of the transient pyramidal neuron population. In order to find the exact origin of cortical neurons that were previously Dbx1-fate mapped we used the promoter region of the murine Dbx1 locus to selectively target Dbx1-expressing progenitors and label their lineage. We found these progenitors in low numbers in all pallial areas, and not only in the ventral pallial ventricular zone. Our findings on the local cortical origin of the Dbx1-derived pyramidal neurons reconcile the observation of Dbx1-derived neurons in the cortex without evidence of dorsal tangential migration from VP and provide a new framework for the origin of the transient Dbx1-derived pyramidal neuron population. We conclude that these neurons are born locally within the dorsal pallial neuroepithelium.es_ES
dc.description.sponsorshipER-A was supported by a Basque Government fellowship. FG-M. was supported by Human Frontiers Science Program Long-Term Postdoctoral Fellowship Program LT000618/2011-L and currently holds an IKERBASQUE research fellowship. ZM holds research grants from the Biotechnology and Biological Sciences Research Council, the Wellcome Trust, and the Medical Research Council United Kingdom. IM-G holds research grants from the Wellcome Trust, the PCDH19 Alliance and the Biotechnology and Biological Sciences Research Council. JME holds MINECO SAF-2015-70866-R (with FEDER funds) and RyC-2012-11137 grants.es_ES
dc.language.isoenges_ES
dc.publisherFrontiers Mediaes_ES
dc.relationinfo:eu-repo/grantAgreement/MINECO/SAF-2015-70866-Res_ES
dc.relationinfo:eu-repo/grantAgreement/MINECO/RyC-2012-11137es_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjecttangential migrationes_ES
dc.subjectventral palliumes_ES
dc.subjectventral migratory streames_ES
dc.subjectclaustrumes_ES
dc.subjectolfactory cortexes_ES
dc.subjectNurr1es_ES
dc.subjectdeveloping cerebral-cortexes_ES
dc.subjectcajal-retzius cellses_ES
dc.subjectglutamatergic neuronses_ES
dc.subjectprogenitor poolses_ES
dc.subjectnervous-systemes_ES
dc.subjectavian braines_ES
dc.subjectmousees_ES
dc.subjectexpressiones_ES
dc.subjectmigrationes_ES
dc.subjectpalliumes_ES
dc.titleDbx1-Derived Pyramidal Neurons Are Generated Locally in the Developing Murine Neocortexes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.holder2018 Rueda-Alaña, Martínez-Garay, Encinas, Molnár and García-Moreno. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.es_ES
dc.rights.holderAtribución 3.0 España*
dc.relation.publisherversionhttps://www.frontiersin.org/articles/10.3389/fnins.2018.00792/fulles_ES
dc.identifier.doi10.3389/fnins.2018.00792
dc.departamentoesNeurocienciases_ES
dc.departamentoeuNeurozientziakes_ES


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2018 Rueda-Alaña, Martínez-Garay, Encinas, Molnár and García-Moreno. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Except where otherwise noted, this item's license is described as 2018 Rueda-Alaña, Martínez-Garay, Encinas, Molnár and García-Moreno. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.