dc.contributor.author | Alonso Gómez, Ángel María | |
dc.contributor.author | Tojal Sierra, Lucas | |
dc.contributor.author | Fortuny Frau, Elena | |
dc.contributor.author | Goicolea Güemez, Leire | |
dc.contributor.author | Aboitiz Uribarri, Ane | |
dc.contributor.author | Portillo Baquedano, María Puy | |
dc.contributor.author | Toledo, Estefanía | |
dc.contributor.author | Schröder, Helmut | |
dc.contributor.author | Salas Salvadó, Jordi | |
dc.contributor.author | Arós Borau, Luis Fernando | |
dc.date.accessioned | 2019-01-21T08:07:18Z | |
dc.date.available | 2019-01-21T08:07:18Z | |
dc.date.issued | 2019-03 | |
dc.identifier.citation | International Journal Of Cardiology. Heart & Vasculature 22 : 67-72 (2019) | es_ES |
dc.identifier.issn | 2352-9067 | |
dc.identifier.uri | http://hdl.handle.net/10810/31063 | |
dc.description.abstract | Background: Left ventricle diastolic dysfunction (LVDD) is a common finding in high risk individuals, its presence being associated with reduced exercise capacity (EC). We assessed the prevalence of LVDD, applying the 2016 guidelines of the American Society of Echocardiography (ASE)/European Association of Cardiovascular Imaging (EACVI), in a population with overweight/obesity and metabolic syndrome and its association with EC.
Methods and results: This was a prospective, cross-sectional study of a cohort of 235 patients (mean age of 65 ± 5 years old and 33% female) without heart disease and an ejection fraction >50% who underwent a complete echocardiographic assessment and cardiopulmonary exercise testing. Individuals meeting three or more criteria of the 2016 ASE/EACVI guidelines are considered to have LVDD, while tests are considered indeterminate in those meeting only two. Overall, 178 (76%) of our patients met one echocardiographic cutoff value for LVDD, 91 (39%) met two and 7 (3%) three or more. Patients meeting three cutoffs values showed a significant reduction in maximal oxygen uptake (16 ± 3 vs. 19.6 ± 5 ml/kg/min, p < .05), unlike those with indeterminate tests. In multiple regression analysis, meeting three cutoffs was associated with number of METS (SS = -2.2, p = .018). In exploratory analysis, using two criteria based on cutoffs different from those proposed in the guidelines, we identified groups with different EC. | es_ES |
dc.description.sponsorship | This work has been funded by the Carlos III Health Institute (Ministry of Economy, Industry and Competitiveness, Spain) through a FIS project coordinated by Dr. Jordi Salas-Salvadó (PI13/01056), by CIBEROBN (Centre for Biomedical Research Network. Physiopathology of Obesity and Nutrition, Spain) and by the European Research Council, European-Union (Advanced Research Grant 2013–2018; 340918) granted to Dr. Miguel A. González-Martínez. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/PI13/01056 | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | * |
dc.subject | diastolic dysfunction | es_ES |
dc.subject | doppler echocardiography | es_ES |
dc.subject | exercise capacity | es_ES |
dc.subject | metabolic syndrome | es_ES |
dc.subject | obesity | es_ES |
dc.title | Diastolic Dysfunction and Exercise Capacity in Patients with Metabolic Syndrome and Overweight/Obesity | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | © 2018 Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license
(http://creativecommons.org/licenses/by-nc-nd/4.0/). | es_ES |
dc.rights.holder | Atribución-NoComercial-SinDerivadas 3.0 España | * |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S2352906718301696?via%3Dihub#! | es_ES |
dc.identifier.doi | 10.1016/j.ijcha.2018.12.010 | |
dc.departamentoes | Farmacia y ciencias de los alimentos | es_ES |
dc.departamentoes | Medicina | es_ES |
dc.departamentoeu | Farmazia eta elikagaien zientziak | es_ES |
dc.departamentoeu | Medikuntza | es_ES |