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dc.contributor.authorAramendia Iradi, Iñigo
dc.contributor.authorFernández Gámiz, Unai
dc.contributor.authorLópez Arraiza, Alberto
dc.contributor.authorRey Santano, María Carmen
dc.contributor.authorMielgo, Victoria
dc.contributor.authorBasterrechea Elguezabal, Francisco José
dc.contributor.authorSancho Saiz, Javier
dc.contributor.authorGómez Solaeche, Miguel Ángel
dc.date.accessioned2019-01-21T08:09:08Z
dc.date.available2019-01-21T08:09:08Z
dc.date.issued2019-01-05
dc.identifier.citationPharmaceutics 11 : (2019) // Article ID 0019es_ES
dc.identifier.issn1999-4923
dc.identifier.urihttp://hdl.handle.net/10810/31064
dc.description.abstractThe potential of non-invasive ventilation procedures and new minimally invasive techniques has resulted in the research of alternative approaches as the aerosolization for the treatment of respiratory distress syndrome (RDS). The aim of this work was to design two nebulizer prototypes and to evaluate them studying the particle size distribution of the inhaled droplets generated with distilled water and two perfluorocarbons (PFCs). Different experiments were performed with driving pressures of 1⁻3 bar for each compound. An Aerodynamic Particle Sizer was used to measure the aerodynamic diameter (Da), the mass median aerodynamic diameter (MMAD) and the geometric standard deviation (GSD). The results showed that both prototypes produced heterodisperse aerosols with Da mean values in all cases below 5 m. The initial experiments with distilled water showed MMAD values lower than 9 m and up to 15 m with prototype 1 and prototype 2, respectively. Regarding the PFCs, relatively uniform MMAD values close to 12 m were achieved. The air delivery with outer lumens of prototype 1 presented more suitable mass distribution for the generation and delivery of a uniform aerosol than the two half-circular ring geometry proposed in the prototype 2.es_ES
dc.description.sponsorshipFunding: This work has been supported by Consolidated Groups from the Basque Government and Fundation VITAL Fundazioa.es_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectaerodynamic particle sizeres_ES
dc.subjectaerosoles_ES
dc.subjectdrug deliveryes_ES
dc.subjectnebulizeres_ES
dc.subjectparticle size distributiones_ES
dc.titleExperimental Evaluation of Perfluorocarbon Aerosol Generation with Two Novel Nebulizer Prototypeses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.holderThis is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).es_ES
dc.rights.holderAtribución 3.0 España*
dc.relation.publisherversionhttps://www.mdpi.com/1999-4923/11/1/19es_ES
dc.identifier.doi10.3390/pharmaceutics11010019
dc.departamentoesCiencias y Técnicas de la Navegación, Máquinas y Construcciones Navaleses_ES
dc.departamentoesIngeniería nuclear y mecánica de fluidoses_ES
dc.departamentoesQuímica físicaes_ES
dc.departamentoeuIngeniaritza nuklearra eta jariakinen mekanikaes_ES
dc.departamentoeuItsasketa zientziak eta teknikakes_ES
dc.departamentoeuKimika fisikoaes_ES


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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
Except where otherwise noted, this item's license is described as This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).