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Extracellular Vesicles in Liver Diseases: Meeting Report from the International Liver Congress 2018

dc.contributor.authorBañales Asurmendi, Jesús María ORCID
dc.contributor.authorFeldstein, Ariel E.
dc.contributor.authorSänger, Hanna
dc.contributor.authorLukacs-Kornek, Veronika
dc.contributor.authorSzabo, Gyongyi
dc.contributor.authorKornek, Miroslaw
dc.date.accessioned2019-03-22T11:25:06Z
dc.date.available2019-03-22T11:25:06Z
dc.date.issued2019-02
dc.identifier.citationHepatology Communications 3(2) : 305-315 (2019)es_ES
dc.identifier.issn2471-254X
dc.identifier.urihttp://hdl.handle.net/10810/32112
dc.description.abstractExtracellular vesicles (EVs) are small and heterogeneous membrane-bound structures released by cells and found in all biological fluids. They are effective intercellular communicators, acting on a number of close and/or distant target cells. EV cargo may reflect the cell of origin as well as the specific stress that induces their formation and release. They transport a variety of bioactive molecules, including messenger RNA, noncoding RNAs, proteins, lipids, and metabolites, that can be transferred among cells, regulating various cell responses. Alteration in the concentration and composition of EVs in biological fluids is a typical hallmark of pathologies in different liver diseases. Circulating EVs can serve as biomarkers or as messengers following uptake by other cells. This review is a meeting report from the International Liver Congress 2018 (European Association for the Study of the Liver) celebrated in Paris (Symposium: Extracellular vesicles and signal transmission) that discusses the role of EVs in several liver diseases, highlighting their potential value as disease biomarkers and therapeutic opportunities.es_ES
dc.description.sponsorshipSupported by the Instituto de Salud Carlos III (grants PI12/00380, PI15/01132, and PI18/01075 to J.M.B.), the Miguel Servet Program (CON14/00129 to J.M.B.), Fondo Europeo de Desarrollo Regional, National Institute for the Study of Liver and Gastrointestinal Diseases (award CIBERehd 2018), Basque Foundation for Science, Spain (award IKERBASQUE 2018), Basque Foundation for Innovation and Health Research (award BIOEF EiTB Maratoia BIO15/CA/016/BD), Department of Health of the Basque Country (grants 2013111173 and 2017111010 to J.M.B.), Scientific Foundation of the Spanish Association Against Cancer (award AECC 2018), and the National Institutes of Health (awards R01 DK113592 and U01 AA024206 to A.E.F., and awards R01AA020744, UH2AA026970 and U01AA026933 to G.S.), the Alexander von Humboldt Foundation, Sofja Kovalevskaja Award 2012 (to V.L-K.) and by the German Research Foundation (LU2061/4-1 to V.L-K. and KO4103/4-1 to M.K.) and by the Deutsche Krebshilfe (111184 to M.K.).es_ES
dc.language.isoenges_ES
dc.publisherWileyes_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.subjecthepatic stellate cellses_ES
dc.subjectnonalcoholic steatohepatitises_ES
dc.subjectmembrane-vesicleses_ES
dc.subjectmicrornaes_ES
dc.subjectmicroparticleses_ES
dc.subjectexosomeses_ES
dc.subjectcholangiocarcinomaes_ES
dc.subjectbiomarkerses_ES
dc.subjectreleasees_ES
dc.subjectproteines_ES
dc.titleExtracellular Vesicles in Liver Diseases: Meeting Report from the International Liver Congress 2018es_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.holderThis is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.es_ES
dc.rights.holderAtribución-NoComercial-SinDerivadas 3.0 España*
dc.relation.publisherversionhttps://aasldpubs.onlinelibrary.wiley.com/doi/full/10.1002/hep4.1300es_ES
dc.identifier.doi10.1002/hep4.1300
dc.departamentoesMedicinaes_ES
dc.departamentoeuMedikuntzaes_ES


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This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
Except where otherwise noted, this item's license is described as This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.