dc.contributor.author | Grijalvo, Santiago | |
dc.contributor.author | Puras Ochoa, Gustavo | |
dc.contributor.author | Zarate Sesma, Jon | |
dc.contributor.author | Sainz Ramos, Myriam | |
dc.contributor.author | Qtaish, Nuseibah A. L. | |
dc.contributor.author | López Méndez, Tania Belén | |
dc.contributor.author | Mashal, Mohamed | |
dc.contributor.author | Attia, Noha | |
dc.contributor.author | Díaz Díaz, David | |
dc.contributor.author | Pons, Ramón | |
dc.contributor.author | Fernández, Eduardo | |
dc.contributor.author | Pedraz Muñoz, José Luis | |
dc.date.accessioned | 2019-03-29T12:25:22Z | |
dc.date.available | 2019-03-29T12:25:22Z | |
dc.date.issued | 2019-02 | |
dc.identifier.citation | Pharmaceutics 11(2) : (2019) // Article ID 50 | es_ES |
dc.identifier.issn | 1999-4923 | |
dc.identifier.uri | http://hdl.handle.net/10810/32216 | |
dc.description.abstract | Cationic niosomes have become important non-viral vehicles for transporting a good number of small drug molecules and macromolecules. Growing interest shown by these colloidal nanoparticles in therapy is determined by their structural similarities to liposomes. Cationic niosomes are usually obtained from the self-assembly of non-ionic surfactant molecules. This process can be governed not only by the nature of such surfactants but also by others factors like the presence of additives, formulation preparation and properties of the encapsulated hydrophobic or hydrophilic molecules. This review is aimed at providing recent information for using cationic niosomes for gene delivery purposes with particular emphasis on improving the transportation of antisense oligonucleotides (ASOs), small interference RNAs (siRNAs), aptamers and plasmids (pDNA). | es_ES |
dc.description.sponsorship | This research was funded by the Spanish Ministerio de Ciencia e Innovacion (MICINN), grant numbers CTQ2017-84415-R, MAT2015-69967-C3-1R, CTQ2017-88948-P, CIBER-BBN, grant numbers CB06_ 01_ 0019, CB06_ 01_ 1028 and CB01_ 01_ 1053, by the Basque Country Government, grant number CGIC10/172 and the Generalitat de Catalunya, grant number 2017/SGR/114, 2017/SGR/670. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | antisense oligonucleotides | es_ES |
dc.subject | aptamers | es_ES |
dc.subject | cationic lipids | es_ES |
dc.subject | cationic niosomes | es_ES |
dc.subject | gene delivery | es_ES |
dc.subject | plasmids | es_ES |
dc.subject | small interference RNA | es_ES |
dc.subject | therapy | es_ES |
dc.subject | nonionic surfactant vesicles | es_ES |
dc.subject | antisense oligonucleotides | es_ES |
dc.subject | drug-delivery | es_ES |
dc.subject | lipid nanoparticles | es_ES |
dc.subject | helper lipids | es_ES |
dc.subject | breast-cancer | es_ES |
dc.subject | transfection efficiency | es_ES |
dc.subject | multidrug-resistance | es_ES |
dc.subject | therapeutic delivery | es_ES |
dc.subject | systemic delivery | es_ES |
dc.title | Cationic Niosomes as Non-Viral Vehicles for Nucleic Acids: Challenges and Opportunities in Gene Delivery | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0). | es_ES |
dc.rights.holder | Atribución 3.0 España | * |
dc.relation.publisherversion | https://www.mdpi.com/1999-4923/11/2/50 | es_ES |
dc.identifier.doi | 10.3390/pharmaceutics11020050 | |
dc.departamentoes | Farmacia y ciencias de los alimentos | es_ES |
dc.departamentoeu | Farmazia eta elikagaien zientziak | es_ES |