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The Crossroad of Ion Channels and Calmodulin in Disease

dc.contributor.authorUrrutia Iñiguez, Janire
dc.contributor.authorAguado Martínez, Alejandra
dc.contributor.authorMuguruza Montero, Arantza
dc.contributor.authorNúñez Viadero, Eider ORCID
dc.contributor.authorMalo de la Fuente, Covadonga
dc.contributor.authorCasis Sáenz, Oscar ORCID
dc.contributor.authorVillarroel Muñoz, Álvaro
dc.date.accessioned2019-03-29T14:09:04Z
dc.date.available2019-03-29T14:09:04Z
dc.date.issued2019-01-02
dc.identifier.citationInternational Journal of Molecular Sciences 20(2) : (2019) // Article ID 400es_ES
dc.identifier.issn1422-0067
dc.identifier.urihttp://hdl.handle.net/10810/32223
dc.description.abstractCalmodulin (CaM) is the principal Ca2+ sensor in eukaryotic cells, orchestrating the activity of hundreds of proteins. Disease causing mutations at any of the three genes that encode identical CaM proteins lead to major cardiac dysfunction, revealing the importance in the regulation of excitability. In turn, some mutations at the CaM binding site of ion channels cause similar diseases. Here we provide a summary of the two sides of the partnership between CaM and ion channels, describing the diversity of consequences of mutations at the complementary CaM binding domains.es_ES
dc.description.sponsorshipThe Department of Industry, Tourism and Trade of the Government of the Autonomous Community of the Basque Country (Elkartek 2017 bG17 kk-2017/000843M50.17.EK.C6) and the Spanish Ministry of Economy, Industry and Competitiveness (BFU2015-66910 and RTI2018-097839) provided financial support for this work. E.N. is supported by a predoctoral grant of the Basque Government.es_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.relationinfo:eu-repo/grantAgreement/MINECO/BFU2015-66910es_ES
dc.relationinfo:eu-repo/grantAgreement/MINECO/RTI2018-097839es_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectcalmodulines_ES
dc.subjection channelses_ES
dc.subjectchannelopathieses_ES
dc.subjectcalciumes_ES
dc.subjectcardiac ryanodine receptores_ES
dc.subjectaxonal surface expressiones_ES
dc.subjectst-segment elevationes_ES
dc.subjectkcnq2 encephalopathyes_ES
dc.subjectca2+ releasees_ES
dc.subjectc-terminuses_ES
dc.subjectiq motifes_ES
dc.subjectmutationses_ES
dc.subjectcalciumes_ES
dc.subjectbindinges_ES
dc.titleThe Crossroad of Ion Channels and Calmodulin in Diseasees_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.holderThis is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).es_ES
dc.rights.holderAtribución 3.0 España*
dc.relation.publisherversionhttps://www.mdpi.com/1422-0067/20/2/400es_ES
dc.identifier.doi10.3390/ijms20020400
dc.departamentoesFisiologíaes_ES
dc.departamentoeuFisiologiaes_ES


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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
Except where otherwise noted, this item's license is described as This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).