Identification of Novel Betaherpesviruses in Iberian Bats Reveals Parallel Evolution
dc.contributor.author | Pozo, Francisco | |
dc.contributor.author | Juste, Javier | |
dc.contributor.author | Vázquez Morón, Sonia | |
dc.contributor.author | Aznar López, Carolina | |
dc.contributor.author | Ibáñez, Carlos | |
dc.contributor.author | Garín Atorrasagasti, Ignacio | |
dc.contributor.author | Aiartza Azurtza, José Ramón | |
dc.contributor.author | Casas, Inmaculada | |
dc.contributor.author | Tenorio, Antonio | |
dc.contributor.author | Echevarría, Juan Emilio | |
dc.date.accessioned | 2019-04-30T09:18:08Z | |
dc.date.available | 2019-04-30T09:18:08Z | |
dc.date.issued | 2016-12-30 | |
dc.identifier.citation | PLOS ONE 11(12) : (2016) // Article ID e0169153 | es_ES |
dc.identifier.issn | 1932-6203 | |
dc.identifier.uri | http://hdl.handle.net/10810/32585 | |
dc.description.abstract | A thorough search for bat herpesviruses was carried out in oropharyngeal samples taken from most of the bat species present in the Iberian Peninsula from the Vespertilionidae, Miniopteridae, Molossidae and Rhinolophidae families, in addition to a colony of captive fruit bats from the Pteropodidae family. By using two degenerate consensus PCR methods targeting two conserved genes, distinct and previously unrecognized bat-hosted herpesviruses were identified for the most of the tested species. All together a total of 42 potentially novel bat herpesviruses were partially characterized. Thirty-two of them were tentatively assigned to the Betaherpesvirinae subfamily while the remaining 10 were allocated into the Gammaherpesvirinae subfamily. Significant diversity was observed among the novel sequences when compared with type herpesvirus species of the ICTV-approved genera. The inferred phylogenetic relationships showed that most of the betaherpesviruses sequences fell into a well-supported unique monophyletic clade and support the recognition of a new betaherpes-virus genus. This clade is subdivided into three major clades, corresponding to the families of bats studied. This supports the hypothesis of a species-specific parallel evolution process between the potentially new betaherpesviruses and their bat hosts. Interestingly, two of the betaherpesviruses' sequences detected in rhinolophid bats clustered together apart from the rest, closely related to viruses that belong to the Roseolovirus genus. This suggests a putative third roseolo lineage. On the contrary, no phylogenetic structure was detected among several potentially novel bat-hosted gammaherpesviruses found in the study. Remarkably, all of the possible novel bat herpesviruses described in this study are linked to a unique bat species. | es_ES |
dc.description.sponsorship | This work was supported by the disappeared Spanish Ministry for Education and Science (grant SAF2006-12784-C02-01), the disappeared Spanish Ministry for Science and Innovation (grant SAF2009-09172) and the Ministry of Economy (grant SAF2013-47194-P). SVM was contracted through an agreement between the Public Health Department of the Spanish Ministry of Health and the Institute de Salud Carlos III for the development of "Rabies Surveillance in Spain". CAL was contracted through the internal research program of the Institute de Salud Carlos III. The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Public Library Science | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/SAF2013-47194-P | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | molecular characterization | es_ES |
dc.subject | mammalian herpesviruses | es_ES |
dc.subject | family | es_ES |
dc.subject | gammaherpesvirus | es_ES |
dc.subject | cytomegalovirus | es_ES |
dc.subject | rhadinoviruses | es_ES |
dc.subject | philogeny | es_ES |
dc.subject | discovery | es_ES |
dc.subject | lineages | es_ES |
dc.subject | homologs | es_ES |
dc.title | Identification of Novel Betaherpesviruses in Iberian Bats Reveals Parallel Evolution | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | © 2016 Pozo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | es_ES |
dc.rights.holder | Atribución 3.0 España | * |
dc.relation.publisherversion | https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0169153 | es_ES |
dc.identifier.doi | 10.1371/journal.pone.0169153 | |
dc.departamentoes | Zoología y biología celular animal | es_ES |
dc.departamentoeu | Zoologia eta animalia zelulen biologia | es_ES |
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Except where otherwise noted, this item's license is described as © 2016 Pozo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.