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dc.contributor.authorPozo, Francisco
dc.contributor.authorJuste, Javier
dc.contributor.authorVázquez Morón, Sonia
dc.contributor.authorAznar López, Carolina
dc.contributor.authorIbáñez, Carlos
dc.contributor.authorGarin Atorrasagasti, Ignacio
dc.contributor.authorAiartza Azurtza, José Ramón
dc.contributor.authorCasas, Inmaculada
dc.contributor.authorTenorio, Antonio
dc.contributor.authorEchevarría, Juan Emilio
dc.date.accessioned2019-04-30T09:18:08Z
dc.date.available2019-04-30T09:18:08Z
dc.date.issued2016-12-30
dc.identifier.citationPLOS ONE 11(12) : (2016) // Article ID e0169153es_ES
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/10810/32585
dc.description.abstractA thorough search for bat herpesviruses was carried out in oropharyngeal samples taken from most of the bat species present in the Iberian Peninsula from the Vespertilionidae, Miniopteridae, Molossidae and Rhinolophidae families, in addition to a colony of captive fruit bats from the Pteropodidae family. By using two degenerate consensus PCR methods targeting two conserved genes, distinct and previously unrecognized bat-hosted herpesviruses were identified for the most of the tested species. All together a total of 42 potentially novel bat herpesviruses were partially characterized. Thirty-two of them were tentatively assigned to the Betaherpesvirinae subfamily while the remaining 10 were allocated into the Gammaherpesvirinae subfamily. Significant diversity was observed among the novel sequences when compared with type herpesvirus species of the ICTV-approved genera. The inferred phylogenetic relationships showed that most of the betaherpesviruses sequences fell into a well-supported unique monophyletic clade and support the recognition of a new betaherpes-virus genus. This clade is subdivided into three major clades, corresponding to the families of bats studied. This supports the hypothesis of a species-specific parallel evolution process between the potentially new betaherpesviruses and their bat hosts. Interestingly, two of the betaherpesviruses' sequences detected in rhinolophid bats clustered together apart from the rest, closely related to viruses that belong to the Roseolovirus genus. This suggests a putative third roseolo lineage. On the contrary, no phylogenetic structure was detected among several potentially novel bat-hosted gammaherpesviruses found in the study. Remarkably, all of the possible novel bat herpesviruses described in this study are linked to a unique bat species.es_ES
dc.description.sponsorshipThis work was supported by the disappeared Spanish Ministry for Education and Science (grant SAF2006-12784-C02-01), the disappeared Spanish Ministry for Science and Innovation (grant SAF2009-09172) and the Ministry of Economy (grant SAF2013-47194-P). SVM was contracted through an agreement between the Public Health Department of the Spanish Ministry of Health and the Institute de Salud Carlos III for the development of "Rabies Surveillance in Spain". CAL was contracted through the internal research program of the Institute de Salud Carlos III. The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.es_ES
dc.language.isoenges_ES
dc.publisherPublic Library Sciencees_ES
dc.relationinfo:eu-repo/grantAgreement/MINECO/SAF2013-47194-Pes_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectmolecular characterizationes_ES
dc.subjectmammalian herpesviruseses_ES
dc.subjectfamilyes_ES
dc.subjectgammaherpesviruses_ES
dc.subjectcytomegaloviruses_ES
dc.subjectrhadinoviruseses_ES
dc.subjectphilogenyes_ES
dc.subjectdiscoveryes_ES
dc.subjectlineageses_ES
dc.subjecthomologses_ES
dc.titleIdentification of Novel Betaherpesviruses in Iberian Bats Reveals Parallel Evolutiones_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.holder© 2016 Pozo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.es_ES
dc.rights.holderAtribución 3.0 España*
dc.relation.publisherversionhttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0169153es_ES
dc.identifier.doi10.1371/journal.pone.0169153
dc.departamentoesZoología y biología celular animales_ES
dc.departamentoeuZoologia eta animalia zelulen biologiaes_ES


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© 2016 Pozo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Except where otherwise noted, this item's license is described as © 2016 Pozo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.