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dc.contributor.authorSetién Olarra, Amaia
dc.contributor.authorMarichalar Mendia, Xabier
dc.contributor.authorGarcía Bediaga, Naiara
dc.contributor.authorAguirre Echevarría, Pablo
dc.contributor.authorAguirre Urizar, José Manuel ORCID
dc.contributor.authorMosqueda Taylor, Adalberto
dc.date.accessioned2019-05-08T08:07:39Z
dc.date.available2019-05-08T08:07:39Z
dc.date.issued2017-10-20
dc.identifier.citationPlos One 12(10) : (2017) // Article ID e0186841es_ES
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/10810/32686
dc.description.abstractObjectives Odontogenic tumors (OT) represent a specific pathological category that includes some lesions with unpredictable biological behavior. Although most of these lesions are benign, some, such as the ameloblastoma, exhibit local aggressiveness and high recurrence rates. The most common types of ameloblastoma are the solid/multicystic (SA) and the unicystic ameloblastoma (UA); the latter considered a much less aggressive entity as compared to the SA. The microRNA system regulates the expression of many human genes while its deregulation has been associated with neoplastic development. The aim of the current study was to determine the expression profiles of microRNAs present in the two most common types of ameloblastomas. Material & methods MicroRNA expression profiles were assessed using TaqMan (R) Low Density Arrays (TLDAs) in 24 samples (8 SA, 8 UA and 8 control samples). The findings were validated using quantitative RTqPCR in an independent cohort of 19 SA, 8 UA and 19 dentigerous cysts as controls. Results We identified 40 microRNAs differentially regulated in ameloblastomas, which are related to neoplastic development and differentiation, and with the osteogenic process. Further validation of the top ranked microRNAs revealed significant differences in the expression of 6 of them in relation to UA, 7 in relation to SA and 1 (miR-489) that was related to both types. Conclusion We identified a new microRNA signature for the ameloblastoma and for its main types, which may be useful to better understand the etiopathogenesis of this neoplasm. In addition, we identified a microRNA (miR-489) that is suggestive of differentiating among solid from unicystic ameloblastoma.es_ES
dc.description.sponsorshipThis research was supported by a Grant from Basque Goverment (IT809-13). The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The authors want to thank Dr. Maria Luisa Gainza Cirauqui for revising the language and style of the manuscript. This research was supported by a Grant from Basque Goverment (IT809-13). Technical and human support provided by SGIker (UPV/EHU, MINECO, GV/EJ, ERDF, and ESF) is gratefully acknowledged.es_ES
dc.language.isoenges_ES
dc.publisherPublic Library Sciencees_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectsquamous-cell carcinomaes_ES
dc.subjecthuman colorectal-canceres_ES
dc.subjectmesenchymal stem-cellses_ES
dc.subjectbreast-canceres_ES
dc.subjectosteogenic differentiationes_ES
dc.subjectpoor-prognosises_ES
dc.subjectoral-carcinomaes_ES
dc.subjecttumores_ES
dc.subjectlunges_ES
dc.subjectmiR-489es_ES
dc.titleMicrornas Expression Profile in Solid and Unicystic Ameloblastomases_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.holderThis is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Attribution 4.0 International (CC BY 4.0)es_ES
dc.rights.holderAtribución 3.0 España*
dc.relation.publisherversionhttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0186841es_ES
dc.identifier.doi10.1371/journal.pone.0186841
dc.departamentoesEnfermeríaes_ES
dc.departamentoesEspecialidades médico-quirúrgicases_ES
dc.departamentoesZoología y biología celular animales_ES
dc.departamentoeuErizaintzaes_ES
dc.departamentoeuMedikuntza eta kirurgia espezialitateakes_ES
dc.departamentoeuZoologia eta animalia zelulen biologiaes_ES


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This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's license is described as This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Attribution 4.0 International (CC BY 4.0)