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Synthesis and Characterization of Covalently Crosslinked pH-Responsive Hyaluronic Acid Nanogels: Effect of Synthesis Parameters

dc.contributor.authorMaiz Fernández, Sheila
dc.contributor.authorPérez Álvarez, Leyre
dc.contributor.authorRuiz Rubio, Leire
dc.contributor.authorPérez González, Raúl
dc.contributor.authorSáez Martínez, Virginia
dc.contributor.authorRuiz Pérez, Jesica
dc.contributor.authorVilas Vilela, José Luis ORCID
dc.date.accessioned2019-05-09T13:09:11Z
dc.date.available2019-05-09T13:09:11Z
dc.date.issued2019-04-24
dc.identifier.citationPolymers 11(4) : (2019) // Article ID 742es_ES
dc.identifier.issn2073-4360
dc.identifier.urihttp://hdl.handle.net/10810/32730
dc.description.abstractStable hyaluronic acid nanogels were obtained following the water-in-oil microemulsion method by covalent crosslinking with three biocompatible crosslinking agents: Divinyl sulfone, 1,4-butanediol diglycidyl ether (BDDE), and poly(ethylene glycol) bis(amine). All nanoparticles showed a pH-sensitive swelling behavior, according to the pKa value of hyaluronic acid, as a consequence of the ionization of the carboxylic moieties, as it was corroborated by zeta potential measurements. QELS studies were carried out to study the influence of the chemical structure of the crosslinking agents on the particle size of the obtained nanogels. In addition, the effect of the molecular weight of the biopolymer and the degree of crosslinking on the nanogels dimensions was also evaluated for BDDE crosslinked nanoparticles, which showed the highest pH-responsive response.es_ES
dc.description.sponsorshipThis research was funded by the Government of the Basque Country (Grupos de Investigación, IT718-13, Frontiers, Programas Hazitek 2017–2018).es_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subject1,4-butanediol diglycidyl etheres_ES
dc.subjectdivinyl sulfonees_ES
dc.subjecthyaluronic acides_ES
dc.subjectnanogelses_ES
dc.subjectpoly(ethylene glycol) bis(amine)es_ES
dc.titleSynthesis and Characterization of Covalently Crosslinked pH-Responsive Hyaluronic Acid Nanogels: Effect of Synthesis Parameterses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.holderThis is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).es_ES
dc.rights.holderAtribución 3.0 España*
dc.relation.publisherversionhttps://www.mdpi.com/2073-4360/11/4/742es_ES
dc.identifier.doi10.3390/polym11040742
dc.departamentoesQuímica físicaes_ES
dc.departamentoeuKimika fisikoaes_ES


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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
Except where otherwise noted, this item's license is described as This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).