Association Between Medication Adherence and Oxidative Stress in Patients With First-Episode Mania
dc.contributor.author | García Fernández, Saínza | |
dc.contributor.author | Alberich, Susana | |
dc.contributor.author | MacDowell, Karina S. | |
dc.contributor.author | Martínez Cengotitabengoa, Mónica | |
dc.contributor.author | López Peña, María Purificación | |
dc.contributor.author | Zorrilla Martínez, Iñaki | |
dc.contributor.author | Leza, Juan Carlos | |
dc.contributor.author | González Pinto Arrillaga, Ana María | |
dc.date.accessioned | 2019-05-10T11:17:39Z | |
dc.date.available | 2019-05-10T11:17:39Z | |
dc.date.issued | 2019-03-26 | |
dc.identifier.citation | Frontiers In Psychiatry 10 : (2019) // Article ID 162 | es_ES |
dc.identifier.issn | 1664-0640 | |
dc.identifier.uri | http://hdl.handle.net/10810/32747 | |
dc.description.abstract | Poor adherence is a major problem in patients with manic episodes that impairs functionality and has unknown effects on oxidative stress. The objective of this study was to analyze the relationship between adherence to medication, severity of symptoms and oxidative stress in a sample of patients with a first episode of mania. A longitudinal, 6-month study was performed in 60 patients, who were classified as adherent and non-adherent to medication (mainly antipsychotics). Blood levels of oxidative stress parameters and expression of the antioxidant nuclear transcription factor NRF2 in mononuclear cells of peripheral blood were assessed at baseline and at the end of follow-up. In addition, clinical symptoms and functioning were evaluated. Linear multivariate regression was used to determine the relationship between adherence, oxidative stress, and clinical symptoms. Finally, 44 patients completed follow-up. The results of this study showed that at 6-month follow-up, adherence was significantly associated with better functioning and reduced clinical symptoms. Additionally, more severe symptoms were associated with increased levels of oxidative stress and antioxidant parameters. At study completion, non-adherents exhibited greater levels of antioxidants than adherent patients. In conclusion, poor adherence to medication is associated with a poorer prognosis in the medium term and causes increased antioxidant response. | es_ES |
dc.description.sponsorship | This study has been funded by Instituto de Salud Carlos III through the projects PI12/02077, PI16/01164, PI14/01900 (Co-funded by European Regional Development Fund/European Social Fund. Investing in your future); the Basque Foundation for Health Innovation and Research (BIOEF); Networking Center for Biomedical Research in Mental Health (CIBERSAM) and the University of the Basque Country (GIC12/84). The psychiatric research department in University Hospital Araba is supported by the Stanley Research Foundation (03-RC-003). SG has a PhD fellowship from the University of the Basque Country. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Frontiers Media | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | medication adherence | es_ES |
dc.subject | oxidative stress | es_ES |
dc.subject | antioxidant activity | es_ES |
dc.subject | bipolar disorder | es_ES |
dc.subject | antipsychotic agents | es_ES |
dc.title | Association Between Medication Adherence and Oxidative Stress in Patients With First-Episode Mania | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | es_ES |
dc.rights.holder | Atribución 3.0 España | * |
dc.relation.publisherversion | https://www.frontiersin.org/articles/10.3389/fpsyt.2019.00162/full | es_ES |
dc.identifier.doi | 10.3389/fpsyt.2019.00162 | |
dc.departamentoes | Farmacia y ciencias de los alimentos | es_ES |
dc.departamentoes | Neurociencias | es_ES |
dc.departamentoeu | Farmazia eta elikagaien zientziak | es_ES |
dc.departamentoeu | Neurozientziak | es_ES |
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