Disease-Associated SNPs in Inflammation-Related lncRNAs
dc.contributor.author | Castellanos Rubio, Ainara | |
dc.contributor.author | Ghosh, Sankar | |
dc.date.accessioned | 2019-05-15T12:36:09Z | |
dc.date.available | 2019-05-15T12:36:09Z | |
dc.date.issued | 2019-03-08 | |
dc.identifier.citation | Frontiers in Immunology 10 : (2019) // Article ID 420 | es_ES |
dc.identifier.issn | 1664-3224 | |
dc.identifier.uri | http://hdl.handle.net/10810/32814 | |
dc.description.abstract | Immune-mediated diseases, such as celiac disease, type 1 diabetes or multiple sclerosis, are a clinically heterogeneous group of diseases that share many key genetic triggers. Although the pathogenic mechanisms responsible for the development of immune mediated disorders is not totally understood, high-throughput genomic studies, such as GWAS and Immunochip, performed in the past few years have provided intriguing hints about underlying mechanisms and pathways that lead to disease. More than a hundred gene variants associated with disease susceptibility have been identified through such studies, but the progress toward understanding the underlying mechanisms has been slow. The majority of the identified risk variants are located in non-coding regions of the genome making it difficult to assign a molecular function to the SNPs. However, recent studies have revealed that many of the non-coding regions bearing disease-associated SNPs generate long non-coding RNAs (lncRNAs). LncRNAs have been implicated in several inflammatory diseases, and many of them have been shown to function as regulators of gene expression. Many of the disease associated SNPs located in lncRNAs modify their secondary structure, or influence expression levels, thereby affecting their regulatory function, hence contributing to the development of disease. | es_ES |
dc.description.sponsorship | AC-R is funded by an Ikerbasque Research Fellowship, SG is funded by grant R01 DK102180 (NIH). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Frontiers Media | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | lncRNA | es_ES |
dc.subject | linc RNA | es_ES |
dc.subject | inflammation | es_ES |
dc.subject | inflammatory disease | es_ES |
dc.subject | GWAS | es_ES |
dc.subject | SNP | es_ES |
dc.subject | long noncoding rna | es_ES |
dc.subject | genome-wide association | es_ES |
dc.subject | celiac-disease | es_ES |
dc.subject | kappa-b | es_ES |
dc.subject | rheumatoid-arthritis | es_ES |
dc.subject | expression analysis | es_ES |
dc.subject | intestinal-mucosa | es_ES |
dc.subject | gene-expression | es_ES |
dc.subject | risk variants | es_ES |
dc.subject | anril | es_ES |
dc.title | Disease-Associated SNPs in Inflammation-Related lncRNAs | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | © 2019 Castellanos-Rubio and Ghosh. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | es_ES |
dc.rights.holder | Atribución 3.0 España | * |
dc.relation.publisherversion | https://www.frontiersin.org/articles/10.3389/fimmu.2019.00420/full | es_ES |
dc.identifier.doi | 10.3389/fimmu.2019.00420 | |
dc.departamentoes | Genética, antropología física y fisiología animal | es_ES |
dc.departamentoeu | Genetika,antropologia fisikoa eta animalien fisiologia | es_ES |
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Except where otherwise noted, this item's license is described as © 2019 Castellanos-Rubio and Ghosh. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.