dc.contributor.author | Nunes Xavier, Caroline E. | |
dc.contributor.author | Zaldumbide Dueñas, Laura | |
dc.contributor.author | Aurtenetxe, Olaia | |
dc.contributor.author | López Almaraz, Ricardo | |
dc.contributor.author | López Fernández de Villaverde, José Ignacio ![ORCID](/themes/Mirage2//images/orcid_16x16.png) | |
dc.contributor.author | Pulido Murillo, Rafael | |
dc.date.accessioned | 2019-05-21T11:00:23Z | |
dc.date.available | 2019-05-21T11:00:23Z | |
dc.date.issued | 2019-03-01 | |
dc.identifier.citation | Molecular Sciences 20(5) : (2019) // Article ID 1170 | es_ES |
dc.identifier.issn | 1422-0067 | |
dc.identifier.uri | http://hdl.handle.net/10810/32894 | |
dc.description.abstract | Dual-specificity phosphatases (DUSPs) are important regulators of neuronal cell growth and differentiation by targeting proteins essential to neuronal survival in signaling pathways, among which the MAP kinases (MAPKs) stand out. DUSPs include the MAPK phosphatases (MKPs), a family of enzymes that directly dephosphorylate MAPKs, as well as the small-size atypical DUSPs, a group of low molecular-weight enzymes which display more heterogeneous substrate specificity. Neuroblastoma (NB) is a malignancy intimately associated with the course of neuronal and neuroendocrine cell differentiation, and constitutes the source of more common extracranial solid pediatric tumors. Here, we review the current knowledge on the involvement of MKPs and small-size atypical DUSPs in NB cell growth and differentiation, and discuss the potential of DUSPs as predictive biomarkers and therapeutic targets in human NB. | es_ES |
dc.description.sponsorship | This work was partially supported by the grants: BIO13/CI/001/BC from BIOEF (EITB maratoia), Basque Country, Spain; SAF2013-48812-R from the Ministerio de Educacion y Ciencia (to R.P.), and SAF2016-79847-R from the Ministerio de Economia y Competitividad (Spain and Fondo Europeo de Desarrollo Regional) (to R.P. and J.I.L.); and 239813 from the Research Council of Norway (to C.E.N-X.). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/SAF2016-79847-R | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | neuroblastoma | es_ES |
dc.subject | neuronal differentiation | es_ES |
dc.subject | dual-specificity phosphatases | es_ES |
dc.subject | MAP kinases | es_ES |
dc.subject | MAP kinase phosphatases | es_ES |
dc.subject | atypical dual-specificity phosphatases | es_ES |
dc.subject | protein-tyrosine phosphatases | es_ES |
dc.subject | neuronal differentiation | es_ES |
dc.subject | down-regulation | es_ES |
dc.subject | up-regulation | es_ES |
dc.subject | signaling pathways | es_ES |
dc.subject | cancer statistics | es_ES |
dc.subject | induced apoptosis | es_ES |
dc.subject | activated ALK | es_ES |
dc.subject | in-vitro | es_ES |
dc.title | Dual-Specificity Phosphatases in Neuroblastoma Cell Growth and Differentiation | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0). | es_ES |
dc.rights.holder | Atribución 3.0 España | * |
dc.relation.publisherversion | https://www.mdpi.com/1422-0067/20/5/1170 | es_ES |
dc.identifier.doi | 10.3390/ijms20051170 | |
dc.departamentoes | Especialidades médico-quirúrgicas | es_ES |
dc.departamentoeu | Medikuntza eta kirurgia espezialitateak | es_ES |