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dc.contributor.authorNunes Xavier, Caroline E.
dc.contributor.authorZaldumbide Dueñas, Laura
dc.contributor.authorAurtenetxe, Olaia
dc.contributor.authorLópez Almaraz, Ricardo
dc.contributor.authorLópez Fernández de Villaverde, José Ignacio
dc.contributor.authorPulido, Rafael
dc.date.accessioned2019-05-21T11:00:23Z
dc.date.available2019-05-21T11:00:23Z
dc.date.issued2019-03-01
dc.identifier.citationMolecular Sciences 20(5) : (2019) // Article ID 1170es_ES
dc.identifier.issn1422-0067
dc.identifier.urihttp://hdl.handle.net/10810/32894
dc.description.abstractDual-specificity phosphatases (DUSPs) are important regulators of neuronal cell growth and differentiation by targeting proteins essential to neuronal survival in signaling pathways, among which the MAP kinases (MAPKs) stand out. DUSPs include the MAPK phosphatases (MKPs), a family of enzymes that directly dephosphorylate MAPKs, as well as the small-size atypical DUSPs, a group of low molecular-weight enzymes which display more heterogeneous substrate specificity. Neuroblastoma (NB) is a malignancy intimately associated with the course of neuronal and neuroendocrine cell differentiation, and constitutes the source of more common extracranial solid pediatric tumors. Here, we review the current knowledge on the involvement of MKPs and small-size atypical DUSPs in NB cell growth and differentiation, and discuss the potential of DUSPs as predictive biomarkers and therapeutic targets in human NB.es_ES
dc.description.sponsorshipThis work was partially supported by the grants: BIO13/CI/001/BC from BIOEF (EITB maratoia), Basque Country, Spain; SAF2013-48812-R from the Ministerio de Educacion y Ciencia (to R.P.), and SAF2016-79847-R from the Ministerio de Economia y Competitividad (Spain and Fondo Europeo de Desarrollo Regional) (to R.P. and J.I.L.); and 239813 from the Research Council of Norway (to C.E.N-X.).es_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.relationinfo:eu-repo/grantAgreement/MINECO/SAF2016-79847-Res_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectneuroblastomaes_ES
dc.subjectneuronal differentiationes_ES
dc.subjectdual-specificity phosphataseses_ES
dc.subjectMAP kinaseses_ES
dc.subjectMAP kinase phosphataseses_ES
dc.subjectatypical dual-specificity phosphataseses_ES
dc.subjectprotein-tyrosine phosphataseses_ES
dc.subjectneuronal differentiationes_ES
dc.subjectdown-regulationes_ES
dc.subjectup-regulationes_ES
dc.subjectsignaling pathwayses_ES
dc.subjectcancer statisticses_ES
dc.subjectinduced apoptosises_ES
dc.subjectactivated ALKes_ES
dc.subjectin-vitroes_ES
dc.titleDual-Specificity Phosphatases in Neuroblastoma Cell Growth and Differentiationes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.holderThis is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).es_ES
dc.rights.holderAtribución 3.0 España*
dc.relation.publisherversionhttps://www.mdpi.com/1422-0067/20/5/1170es_ES
dc.identifier.doi10.3390/ijms20051170
dc.departamentoesEspecialidades médico-quirúrgicases_ES
dc.departamentoeuMedikuntza eta kirurgia espezialitateakes_ES


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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
Except where otherwise noted, this item's license is described as This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).