dc.contributor.author | Cespón, J. | |
dc.contributor.author | Rodella, C. | |
dc.contributor.author | Miniussi, C. | |
dc.contributor.author | Pellicciari, MC. | |
dc.date.accessioned | 2019-10-02T07:08:43Z | |
dc.date.available | 2019-10-02T07:08:43Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | J. Cespón, C. Rodella, C. Miniussi, M.C. Pellicciari, Behavioural and electrophysiological modulations induced by transcranial direct current stimulation in healthy elderly and Alzheimer’s disease patients: A pilot study, Clinical Neurophysiology, Volume 130, Issue 11, 2019, Pages 2038-2052, https://doi.org/10.1016/j.clinph.2019.08.016. | es_ES |
dc.identifier.issn | 1388-2457 | |
dc.identifier.uri | http://hdl.handle.net/10810/35563 | |
dc.description | Available online 26 August 2019 | es_ES |
dc.description.abstract | Objective
To investigate whether anodal and cathodal transcranial direct current stimulation (tDCS) can modify cognitive performance and neural activity in healthy elderly and Alzheimer’s disease (AD) patients.
Methods
Fourteen healthy elderly and twelve AD patients performed a working memory task during an electroencephalogram recording before and after receiving anodal, cathodal, and sham tDCS over the left dorsolateral prefrontal cortex. Behavioural performance, event-related potentials (P200, P300) and evoked cortical oscillations were studied as correlates of working memory.
Results
Anodal tDCS increased P200 and P300 amplitudes in healthy elderly. Cathodal tDCS increased P200 amplitude and frontal theta activity between 150 and 300 ms in AD patients. Improved working memory after anodal tDCS correlated with increased P300 in healthy elderly. In AD patients, slight tendencies between enhanced working memory and increased P200 after cathodal tDCS were observed.
Conclusions
Functional neural modulations were promoted by anodal tDCS in healthy elderly and by cathodal tDCS in AD patients.
Significance
Interaction between tDCS polarity and the neural state (e.g., hyper-excitability exhibited by AD patients) suggests that appropriate tDCS parameters (in terms of tDCS polarity) to induce behavioural improvements should be chosen based on the participant’s characteristics. Future studies using higher sample sizes should confirm and extend the present findings. | es_ES |
dc.description.sponsorship | This study was funded by the Italian Ministry of Health GR-2011-02349998 to MCP and the European Commission Marie-Skłodowska Curie Actions, Individual Fellowships; 655423-NIBSAD to JC. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Clinical Neurophysiology | es_ES |
dc.relation | info:eu-repo/grantAgreement/EC/H2020/MC/655423 | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Transcranial direct current stimulation | es_ES |
dc.subject | Working memory | es_ES |
dc.subject | Alzheimer’s disease | es_ES |
dc.subject | Event-related potentials | es_ES |
dc.subject | Compensatory mechanisms | es_ES |
dc.title | Behavioural and electrophysiological modulations induced by transcranial direct current stimulation in healthy elderly and Alzheimer’s disease patients: A pilot study | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | © 2019 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved. | es_ES |
dc.relation.publisherversion | https://www.sciencedirect.com/journal/clinical-neurophysiology | es_ES |
dc.identifier.doi | 10.1016/j.clinph.2019.08.016 | |