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dc.contributor.authorAlberich, Susana
dc.contributor.authorFernandez Sevillano, Jessica
dc.contributor.authorGonzalez Ortega, Itxaso
dc.contributor.authorUsall, Judith
dc.contributor.authorSaenz Herrero, Margarita
dc.contributor.authorGonzalez Fraile, Eduardo
dc.contributor.authorGonzalez Pinto Arrillaga, Ana Maria
dc.identifier.citationPsychiatry Research 280 : (2019) // Article ID 112506es_ES
dc.description.abstractClozapine is one of the most widely used antipsychotics for treating psychiatric illnesses such as schizophrenia and bipolar disorder. This drug, however, is associated with adverse effects such as weight gain, metabolic syndrome, and blood dyscrasias. The manifestations of mental illness may differ between men and women. Yet, there is little evidence on the influence of sex on treatment response or the occurrence of AEs. To fill this gap of knowledge, we carried out a systematic review of the literature on sex differences in the effectiveness and adverse effects of clozapine. Scant evidence has been published on differences in effectiveness of clozapine between men and women. Indeed, to the best of our knowledge, this issue has only been addressed in a published study. Regarding adverse effects, males have been reported to be more likely to develop metabolic abnormalities such as cholesterol or triglycerides, hypertension, and cardiovascular risk, while females are at a higher risk for gaining weight, developing diabetes, and needing laxatives. Nevertheless, given the scarcity of sex-based studies on this drug, further studies are needed to explore sex-based differences, as the results obtained may be crucial to clinical practice and help improve the quality of life of patients.es_ES
dc.description.sponsorshipThis study was funded by Carlos III Health Research Institute [grant numbers PI13/00451, PI13/02252, PI14/01900, PI15/00793, PI15/00789 and PI16/01164 (co-financed by the European Regional Development Fund/European Social Fund, "Investing in your future)]. We would also like to acknowledge support from the Basque Foundation for Health Innovation and Research (BIOEF); Networking Center for Biomedical Research in Mental Health (CIBERSAM); the Basque Government [grant number 2015111024]; and the University of the Basque Country [grant number 321212ELBY]. The psychiatric research department in Araba University Hospital is supported by the Stanley Research Foundation [grant number 03-RC-003].es_ES
dc.subjectadverse effectses_ES
dc.subjectbody-mass indexes_ES
dc.subjectatypical antipsychoticses_ES
dc.subjectqtc prolongationes_ES
dc.subjectplasma clozapinees_ES
dc.titleA systematic review of sex-based differences in effectiveness and adverse effects of clozapinees_ES
dc.rights.holder© 2019 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND licensees_ES
dc.rights.holderAtribución-NoComercial-SinDerivadas 3.0 España*

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© 2019 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license
Except where otherwise noted, this item's license is described as © 2019 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license