Glycans in drug discovery
dc.contributor.author | Valverde, Pablo | |
dc.contributor.author | Ardá, Ana | |
dc.contributor.author | Reichardt, Niels Christian | |
dc.contributor.author | Jiménez Barbero, Jesús | |
dc.contributor.author | Gimeno, Ana | |
dc.date.accessioned | 2019-12-03T08:50:35Z | |
dc.date.available | 2019-12-03T08:50:35Z | |
dc.date.issued | 2019-07-26 | |
dc.identifier.citation | MEDCHEMCOMM 10(10) : 1678-1691 (2019) | es_ES |
dc.identifier.issn | 2040-2503 | |
dc.identifier.issn | 2040-2511 | |
dc.identifier.uri | http://hdl.handle.net/10810/36666 | |
dc.description.abstract | Glycans are key players in many biological processes. They are essential for protein folding and stability and act as recognition elements in cell-cell and cell-matrix interactions. Thus, being at the heart of medically relevant biological processes, glycans have come onto the scene and are considered hot spots for biomedical intervention. The progress in biophysical techniques allowing access to an increasing molecular and structural understanding of these processes has led to the development of effective therapeutics. Indeed, strategies aimed at designing glycomimetics able to block specific lectin-carbohydrate interactions, carbohydrate-based vaccines mimicking self- and non-self-antigens as well as the exploitation of the therapeutic potential of glycosylated antibodies are being pursued. In this mini-review the most prominent contributions concerning recurrent diseases are highlighted, including bacterial and viral infections, cancer or immune-related pathologies, which certainly show the great promise of carbohydrates in drug discovery. | es_ES |
dc.description.sponsorship | We thank the European Research Council for financial support (ERC-2017-AdG, project number 788143-RECGLYCANMR). We also thank Instituto de Salud Carlos III of Spain, ISCIII (grant PRB3 IPT17/0019 to A. G.) and Agencia Estatal Investigacion of Spain, AEI (grants CTQ2015-64597-C2-1-P and RTI2018-094751-B-C21 and the Severo Ochoa Excellence Accreditation SEV-2016-0644). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Royal Soc Chemistry | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/3.0/es/ | * |
dc.subject | chondroitin sulfate proteoglycan | es_ES |
dc.subject | mass-spectrometry methods | es_ES |
dc.subject | high-affinity inhibitors | es_ES |
dc.subject | dc-sign | es_ES |
dc.subject | monoclonal-antibodies | es_ES |
dc.subject | heparan-sulfate | es_ES |
dc.subject | therapeutic glycoproteins | es_ES |
dc.subject | glycosylation profiles | es_ES |
dc.subject | chemical-synthesis | es_ES |
dc.subject | lectin inhibition | es_ES |
dc.title | Glycans in drug discovery | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material and it is not used for commercial purposes. Reproduced material should be attributed as follows: For reproduction of material from NJC: [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC. For reproduction of material from PCCP: [Original citation] - Published by the PCCP Owner Societies. For reproduction of material from PPS: [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC. For reproduction of material from all other RSC journals: [Original citation] - Published by The Royal Society of Chemistry. | es_ES |
dc.rights.holder | Atribución-NoComercial 3.0 España | * |
dc.relation.publisherversion | https://pubs.rsc.org/en/content/articlepdf/2019/md/c9md00292h | es_ES |
dc.identifier.doi | 10.1039/c9md00292h | |
dc.departamentoes | Química orgánica II | es_ES |
dc.departamentoeu | Kimika organikoa II | es_ES |
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Reproduced material should be attributed as follows:
For reproduction of material from NJC:
[Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
For reproduction of material from PCCP:
[Original citation] - Published by the PCCP Owner Societies.
For reproduction of material from PPS:
[Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
For reproduction of material from all other RSC journals:
[Original citation] - Published by The Royal Society of Chemistry.