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dc.contributor.authorGandia Aguado, David
dc.contributor.authorGandarias Albaina, Lucia
dc.contributor.authorRodrigo Arrizabalaga, Irati
dc.contributor.authorRobles García, Joshua
dc.contributor.authorDas, Raja
dc.contributor.authorGaraio Urabaien, Eneko
dc.contributor.authorGarcía Martínez, José Angel
dc.contributor.authorPhan, Manh Huong
dc.contributor.authorSrikanth, Hariharan
dc.contributor.authorOrue Goikuria, Iñaki
dc.contributor.authorAlonso, Javier
dc.contributor.authorMuela Blázquez, Alicia
dc.contributor.authorFernández Gubieda Ruiz, María Luisa
dc.date.accessioned2019-12-18T12:41:23Z
dc.date.available2019-12-18T12:41:23Z
dc.date.issued2019-10
dc.identifier.citationSmall 15(41) : (2019) // Article ID 1902626es_ES
dc.identifier.issn1613-6810
dc.identifier.issn1613-6829
dc.identifier.urihttp://hdl.handle.net/10810/36927
dc.description.abstractMagnetotactic bacteria are aquatic microorganisms that internally biomineralize chains of magnetic nanoparticles (called magnetosomes) and use them as a compass. Here it is shown that magnetotactic bacteria of the strain Magnetospirillum gryphiswaldense present high potential as magnetic hyperthermia agents for cancer treatment. Their heating efficiency or specific absorption rate is determined using both calorimetric and AC magnetometry methods at different magnetic field amplitudes and frequencies. In addition, the effect of the alignment of the bacteria in the direction of the field during the hyperthermia experiments is also investigated. The experimental results demonstrate that the biological structure of the magnetosome chain of magnetotactic bacteria is perfect to enhance the hyperthermia efficiency. Furthermore, fluorescence and electron microscopy images show that these bacteria can be internalized by human lung carcinoma cells A549, and cytotoxicity studies reveal that they do not affect the viability or growth of the cancer cells. A preliminary in vitro hyperthermia study, working on clinical conditions, reveals that cancer cell proliferation is strongly affected by the hyperthermia treatment, making these bacteria promising candidates for biomedical applications.es_ES
dc.description.sponsorshipD.G. and L.G. contributed equally to this work. The authors would like to thank Nanobioap cluster of excellence. Spanish Government is acknowledged for funding under the project number MAT2017-83631-C3. USF coauthors acknowledge support from U.S. Department of Energy, Office of Basic Energy Sciences under Award No. DE-FG02-07ER46438. The authors specially thank Prof. Ana Garcia-Prieto for her critical revision of the article and her helpful suggestions.es_ES
dc.language.isoenges_ES
dc.publisherWileyes_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectcancer therapyes_ES
dc.subjectcytotoxicityes_ES
dc.subjectinternalizationes_ES
dc.subjectmagnetic hyperthermiaes_ES
dc.subjectmagnetotactic bacteriaes_ES
dc.subjectnanoparticleses_ES
dc.subjectmagnetosomeses_ES
dc.subjectcanceres_ES
dc.subjecttumorses_ES
dc.subjectnanomedicinees_ES
dc.subjectlimitationses_ES
dc.titleUnlocking the Potential of Magnetotactic Bacteria as Magnetic Hyperthermia Agentses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.holderThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. The copyright line for this article was changed on 19 October 2019 after original online publication.es_ES
dc.rights.holderAtribución 3.0 España*
dc.relation.publisherversionhttps://onlinelibrary.wiley.com/doi/full/10.1002/smll.201902626es_ES
dc.identifier.doi10.1002/smll.201902626
dc.departamentoesElectricidad y electrónicaes_ES
dc.departamentoesFísica aplicada IIes_ES
dc.departamentoesInmunología, microbiología y parasitologíaes_ES
dc.departamentoeuElektrizitatea eta elektronikaes_ES
dc.departamentoeuFisika aplikatua IIes_ES
dc.departamentoeuImmunologia, mikrobiologia eta parasitologiaes_ES


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This is an open access article under the terms of the Creative
Commons Attribution License, which permits use, distribution and
reproduction in any medium, provided the original work is properly cited.
The copyright line for this article was changed on 19 October 2019 after
original online publication.
Except where otherwise noted, this item's license is described as This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. The copyright line for this article was changed on 19 October 2019 after original online publication.