Unlocking the Potential of Magnetotactic Bacteria as Magnetic Hyperthermia Agents
dc.contributor.author | Gandia Aguado, David | |
dc.contributor.author | Gandarias Albaina, Lucia | |
dc.contributor.author | Rodrigo Arrizabalaga, Irati | |
dc.contributor.author | Robles García, Joshua | |
dc.contributor.author | Das, Raja | |
dc.contributor.author | Garaio Urabaien, Eneko | |
dc.contributor.author | García Martínez, José Angel | |
dc.contributor.author | Phan, Manh Huong | |
dc.contributor.author | Srikanth, Hariharan | |
dc.contributor.author | Orue Goikuria, Iñaki | |
dc.contributor.author | Alonso, Javier | |
dc.contributor.author | Muela Blázquez, Alicia | |
dc.contributor.author | Fernández Gubieda Ruiz, María Luisa | |
dc.date.accessioned | 2019-12-18T12:41:23Z | |
dc.date.available | 2019-12-18T12:41:23Z | |
dc.date.issued | 2019-10 | |
dc.identifier.citation | Small 15(41) : (2019) // Article ID 1902626 | es_ES |
dc.identifier.issn | 1613-6810 | |
dc.identifier.issn | 1613-6829 | |
dc.identifier.uri | http://hdl.handle.net/10810/36927 | |
dc.description.abstract | Magnetotactic bacteria are aquatic microorganisms that internally biomineralize chains of magnetic nanoparticles (called magnetosomes) and use them as a compass. Here it is shown that magnetotactic bacteria of the strain Magnetospirillum gryphiswaldense present high potential as magnetic hyperthermia agents for cancer treatment. Their heating efficiency or specific absorption rate is determined using both calorimetric and AC magnetometry methods at different magnetic field amplitudes and frequencies. In addition, the effect of the alignment of the bacteria in the direction of the field during the hyperthermia experiments is also investigated. The experimental results demonstrate that the biological structure of the magnetosome chain of magnetotactic bacteria is perfect to enhance the hyperthermia efficiency. Furthermore, fluorescence and electron microscopy images show that these bacteria can be internalized by human lung carcinoma cells A549, and cytotoxicity studies reveal that they do not affect the viability or growth of the cancer cells. A preliminary in vitro hyperthermia study, working on clinical conditions, reveals that cancer cell proliferation is strongly affected by the hyperthermia treatment, making these bacteria promising candidates for biomedical applications. | es_ES |
dc.description.sponsorship | D.G. and L.G. contributed equally to this work. The authors would like to thank Nanobioap cluster of excellence. Spanish Government is acknowledged for funding under the project number MAT2017-83631-C3. USF coauthors acknowledge support from U.S. Department of Energy, Office of Basic Energy Sciences under Award No. DE-FG02-07ER46438. The authors specially thank Prof. Ana Garcia-Prieto for her critical revision of the article and her helpful suggestions. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Wiley | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | cancer therapy | es_ES |
dc.subject | cytotoxicity | es_ES |
dc.subject | internalization | es_ES |
dc.subject | magnetic hyperthermia | es_ES |
dc.subject | magnetotactic bacteria | es_ES |
dc.subject | nanoparticles | es_ES |
dc.subject | magnetosomes | es_ES |
dc.subject | cancer | es_ES |
dc.subject | tumors | es_ES |
dc.subject | nanomedicine | es_ES |
dc.subject | limitations | es_ES |
dc.title | Unlocking the Potential of Magnetotactic Bacteria as Magnetic Hyperthermia Agents | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. The copyright line for this article was changed on 19 October 2019 after original online publication. | es_ES |
dc.rights.holder | Atribución 3.0 España | * |
dc.relation.publisherversion | https://onlinelibrary.wiley.com/doi/full/10.1002/smll.201902626 | es_ES |
dc.identifier.doi | 10.1002/smll.201902626 | |
dc.departamentoes | Electricidad y electrónica | es_ES |
dc.departamentoes | Física aplicada II | es_ES |
dc.departamentoes | Inmunología, microbiología y parasitología | es_ES |
dc.departamentoeu | Elektrizitatea eta elektronika | es_ES |
dc.departamentoeu | Fisika aplikatua II | es_ES |
dc.departamentoeu | Immunologia, mikrobiologia eta parasitologia | es_ES |
Files in this item
This item appears in the following Collection(s)
Except where otherwise noted, this item's license is described as This is an open access article under the terms of the Creative
Commons Attribution License, which permits use, distribution and
reproduction in any medium, provided the original work is properly cited.
The copyright line for this article was changed on 19 October 2019 after
original online publication.