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dc.contributor.authorAristieta Arbelaiz, Asier
dc.contributor.authorRuiz Ortega, José Ángel
dc.contributor.authorMorera Herreras, Teresa
dc.contributor.authorMiguélez Palomo, Cristina
dc.contributor.authorUgedo Urruela, Luisa
dc.date.accessioned2019-12-19T13:54:05Z
dc.date.available2019-12-19T13:54:05Z
dc.date.issued2019-12
dc.identifier.citationExperimental neurology 322 : (2019) // Article ID 113036es_ES
dc.identifier.issn1090-2430
dc.identifier.urihttp://hdl.handle.net/10810/37046
dc.description.abstractThe pathophysiology of Parkinson's disease (PD) and L-DOPA-induced dyskinesia (LID) is associated with aberrant neuronal activity and abnormal high levels of oscillatory activity and synchronization in several basal ganglia nuclei and the cortex. Previously, we have shown that the firing activity of neurons in the substantia nigra pars reticulata (SNr) is relevant in dyskinesia and may be driven by subthalamic nucleus (STN) hyperactivity. Conversely, low frequency oscillatory activity and synchronization in these structures seem to be more important in PD because they are not influenced by prolonged L-DOPA administration. The aim of the present study was to assess (through single-unit extracellular recording techniques under urethane anaesthesia) the neuronal activity of the entopeduncular nucleus (EPN) and its relationship with LID and STN hyperactivity, together with the oscillatory activity and synchronization between these nuclei and the cerebral cortex in 6-OHDA-lesioned rats that received long term L-DOPA treatment (or not). Twenty-four hours after the last L-DOPA injection the firing activity of EPN neurons in long term L-DOPA treated 6-OHDA-lesioned rats was more irregular and bursting compared to sham rats, being those alterations partially reversed by the acute challenge of L-DOPA. No correlation between EPN neurons firing activity and abnormal involuntary movements score was found. However, there was a significant correlation between the firing activity parameters of EPN and STN neurons recorded from long term L-DOPA treated 6-OHDA-lesioned rats. Low frequency oscillatory activity and synchronization both within the EPN and with the cerebral cortex were enhanced in 6-OHDA-lesioned animals. These changes were reversed by the acute L-DOPA challenge only in long term L-DOPA treated 6-OHDA-lesioned rats. Altogether, these results obtained from long term L-DOPA treated 6-OHDA-lesioned rats suggest (1) a likely relationship between STN and EPN firing patterns and spiking phases induced by changes after prolonged L-DOPA administration and (2) that the effect of L-DOPA on the firing pattern, low frequency oscillatory activity and synchronization in the EPN may have a relevant role in LID.es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subject6-OHDAes_ES
dc.subjectBasal gangliaes_ES
dc.subjectdyskinesiaes_ES
dc.subjectelectrophysiologyes_ES
dc.subjectentopeduncular nucleuses_ES
dc.subjectin vivoes_ES
dc.subjectL-DOPAes_ES
dc.subjectlow oscillatory activityes_ES
dc.subjectParkinson's diseasees_ES
dc.subjectsubthalamic nucleuses_ES
dc.titleAcute L-DOPA administration reverses changes in firing pattern and low frequency oscillatory activity in the entopeduncular nucleus from long term L-DOPA treated 6-OHDA-lesioned ratses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.holder© 2019 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/BY/4.0/)es_ES
dc.rights.holderAtribución 3.0 España*
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0014488619301852?via%3Dihubes_ES
dc.identifier.doi10.1016/j.expneurol.2019.113036
dc.departamentoesFarmacologíaes_ES
dc.departamentoesMedicinaes_ES
dc.departamentoeuFarmakologiaes_ES
dc.departamentoeuMedikuntzaes_ES


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© 2019 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/BY/4.0/)
Except where otherwise noted, this item's license is described as © 2019 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/BY/4.0/)