dc.contributor.author | Díaz Tajada, Esperanza | |
dc.contributor.author | Valle García, María Blanca | |
dc.contributor.author | Ribeiro, Sylvie | |
dc.contributor.author | Lanceros Méndez, Senentxu | |
dc.contributor.author | Barandiarán García, José Manuel | |
dc.date.accessioned | 2020-01-15T08:27:11Z | |
dc.date.available | 2020-01-15T08:27:11Z | |
dc.date.issued | 2019-09-20 | |
dc.identifier.citation | International Journal Of Molecular Sciences 20(19) : (2019) // Article ID 4664 | es_ES |
dc.identifier.issn | 1422-0067 | |
dc.identifier.uri | http://hdl.handle.net/10810/38463 | |
dc.description.abstract | Magnetic biomimetic scaffolds of poly(L-lactide) (PLLA) and nanoparticles of magnetite (nFe(3)O(4)) are prepared in a wide ratio of compositions by lyophilization for bone regeneration. The magnetic properties, cytotoxicity, and the in vitro degradation of these porous materials are closely studied. The addition of magnetite at 50 degrees C was found to produce an interaction reaction between the ester groups of the PLLA and the metallic cations of the magnetite, causing the formation of complexes. This fact was confirmed by the analysis of the infrared spectroscopy and the gel permeation chromatography test results. They, respectively, showed a displacement of the absorption bands of the carbonyl group (C=O) of the PLLA and a scission of the polymer chains. The iron from the magnetite acted as a catalyser of the macromolecular scission reaction, which determines the final biomedical applications of the scaffolds-it does so because the reaction shortens the degradation process without appearing to influence its toxicity. None of the samples studied in the tests presented cytotoxicity, even at 70% magnetite concentrations. | es_ES |
dc.description.sponsorship | This work was supported by the Spanish Ministry of Economy and Competitiveness (MINECO) through the project MAT2016-76039-C4-3-R (AEI/FEDER, UE) and from the Basque Government Industry Department under the ELKARTEK, HAZITEK and PIBA programs. Supported by the Portuguese Foundation for Science and Technology (FCT) in the framework of the Strategic Funding UID/FIS/04650/2013, project POCI-01-0145-FEDER-028237 and grant SFRH/BD/111478/2015 (S.R.) is acknowledged. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/MAT2016-76039-C4-3-R | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | polymer scission | es_ES |
dc.subject | PLLA | es_ES |
dc.subject | magnetite | es_ES |
dc.subject | cytotoxicity | es_ES |
dc.subject | magnetism | es_ES |
dc.subject | in vitro degradation | es_ES |
dc.subject | in-vitro | es_ES |
dc.subject | cell transplantation | es_ES |
dc.subject | epsilon-caprolactone | es_ES |
dc.subject | degradation | es_ES |
dc.subject | proliferation | es_ES |
dc.subject | angiogenesis | es_ES |
dc.subject | osteoblast | es_ES |
dc.subject | implants | es_ES |
dc.subject | fiber | es_ES |
dc.title | A New Approach for the Fabrication of Cytocompatible PLLA-Magnetite Nanoparticle Composite Scaffolds | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0) | es_ES |
dc.rights.holder | Atribución 3.0 España | * |
dc.relation.publisherversion | https://www.mdpi.com/1422-0067/20/19/4664 | es_ES |
dc.identifier.doi | 10.3390/ijms20194664 | |
dc.departamentoes | Electricidad y electrónica | es_ES |
dc.departamentoes | Ingeniería Minera y Metalúrgica y Ciencia de los Materiales | es_ES |
dc.departamentoeu | Elektrizitatea eta elektronika | es_ES |
dc.departamentoeu | Meatze eta metalurgia ingeniaritza materialen zientzia | es_ES |