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dc.contributor.authorEspona Noguera, Albert
dc.contributor.authorCiriza Astrain, Jesús
dc.contributor.authorCañibano Hernández, Alberto
dc.contributor.authorOrive Arroyo, Gorka
dc.contributor.authorHernández Martín, Rosa María
dc.contributor.authorSáenz del Burgo Martínez, Laura
dc.contributor.authorPedraz Muñoz, José Luis
dc.date.accessioned2020-02-05T12:51:01Z
dc.date.available2020-02-05T12:51:01Z
dc.date.issued2019-11-12
dc.identifier.citationPharmaceutics 11(11) : (2019) // Article ID 597es_ES
dc.identifier.issn1999-4923
dc.identifier.urihttp://hdl.handle.net/10810/40427
dc.description.abstractType 1 Diabetes Mellitus (T1DM) is characterized by the autoimmune destruction of beta-cells in the pancreatic islets. In this regard, islet transplantation aims for the replacement of the damaged beta-cells through minimally invasive surgical procedures, thereby being the most suitable strategy to cure T1DM. Unfortunately, this procedure still has limitations for its widespread clinical application, including the need for long-term immunosuppression, the lack of pancreas donors and the loss of a large percentage of islets after transplantation. To overcome the aforementioned issues, islets can be encapsulated within hydrogel-like biomaterials to diminish the loss of islets, to protect the islets resulting in a reduction or elimination of immunosuppression and to enable the use of other insulin-producing cell sources. This review aims to provide an update on the different hydrogel-based encapsulation strategies of insulin-producing cells, highlighting the advantages and drawbacks for a successful clinical application.es_ES
dc.description.sponsorshipAuthors thank the support to research on cell microencapsulation from the University of the Basque Country UPV/EHU (EHUa16/06 to L.SB) and the Basque Country Government (Grupos Consolidados, ref. no.: IT907-16 to J.L. P). Authors also thank ICTS "NANBIOSIS", specifically by the Drug Formulation Unit (U10) of the CIBER in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN) at the University of Basque Country UPV/EHU in Vitoria-Gasteiz.es_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjecttype 1 diabetes mellituses_ES
dc.subjecthydrogeles_ES
dc.subjectnanoencapsulationes_ES
dc.subjectmicroencapsulationes_ES
dc.subjectmacroencapsulationes_ES
dc.subjectbioprintinges_ES
dc.subjectalginate-based microcapsuleses_ES
dc.subjectislet transplantationes_ES
dc.subjectbioartificial pancreases_ES
dc.subjectporcine isletses_ES
dc.subjectpig isletses_ES
dc.subjectmultilayer nanoencapsulationes_ES
dc.subjectpolyethylene-glycoles_ES
dc.subjectimmunoisolationes_ES
dc.subjectdesignes_ES
dc.subjectstrategieses_ES
dc.titleReview of Advanced Hydrogel-Based Cell Encapsulation Systems for Insulin Delivery in Type 1 Diabetes Mellituses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.holderThis is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.es_ES
dc.rights.holderAtribución 3.0 España*
dc.relation.publisherversionhttps://www.mdpi.com/1999-4923/11/11/597es_ES
dc.identifier.doi10.3390/pharmaceutics11110597
dc.departamentoesFarmacia y ciencias de los alimentoses_ES
dc.departamentoeuFarmazia eta elikagaien zientziakes_ES


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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Except where otherwise noted, this item's license is described as This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.