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dc.contributor.authorMartín Laza, Imanol
dc.contributor.authorHervella Afonso, Montserrat
dc.contributor.authorNeira Zubieta, Mikel
dc.contributor.authorDe la Rúa Vaca, Concepción
dc.date.accessioned2020-02-17T13:11:00Z
dc.date.available2020-02-17T13:11:00Z
dc.date.issued2019-12-31
dc.identifier.citationScientific Reports 9 : (2019) // Article ID 20380es_ES
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/10810/41148
dc.description.abstractAmong the factors that would explain the distribution of mitochondrial lineages in Europe, climate and diseases may have played an important role. A possible explanation lies in the nature of the mitochondrion, in which the energy generation process produces reactive oxygen species that may influence the development of different diseases. The present study is focused on the medieval necropolis of San Miguel de Erenozar (13th-16th centuries, Basque Country), whose inhabitants presented a high prevalence of rheumatic diseases and lived during the Little Ice Age (LIA). Our results indicate a close relationship between rheumatic diseases and mitochondrial haplogroup H, and specifically between spondyloarthropathies and sub-haplogroup H2. One possible explanation may be the climate change that took place in the LIA that favoured those haplogroups that were more energy-efficient, such as haplogroup H, to endure lower temperatures and food shortage. However, it had a biological trade-off: the increased risk of developing rheumatic diseases.es_ES
dc.description.sponsorshipThis work was supported by the Spanish Ministry of Economy, Industry and Competitiveness (GCL2016-79093/P), and grants from the Basque Government to Research Groups of the Basque University System (IT1138-16) and to Imanol Martin Laza (2014_1_326). We are grateful to the Institutions that granted permission for human remains study, including the Cultural Heritage Department of the Government of the Basque Country and the Archaeology Museum of Bizkaia.es_ES
dc.language.isoenges_ES
dc.publisherNaturees_ES
dc.relationinfo:eu-repo/grantAgreement/MINECO/GCL2016-79093/Pes_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectradiographic progressiones_ES
dc.subjectdegenerative diseaseses_ES
dc.subjecthaplogroups modulatees_ES
dc.subjectmtdna haplogroups;es_ES
dc.subjectosteoarthritises_ES
dc.subjectmetaanalysises_ES
dc.subjectapoptosises_ES
dc.subjectvariantses_ES
dc.subjectriskes_ES
dc.subjectrecolonizationes_ES
dc.titleEnvironmental factors modulated ancient mitochondrial DnA variability and the prevalence of rheumatic diseases in the Basque countryes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.holderThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Cre-ative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not per-mitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.es_ES
dc.rights.holderAtribución 3.0 España*
dc.relation.publisherversionhttps://www.nature.com/articles/s41598-019-56921-xes_ES
dc.identifier.doi10.1038/s41598-019-56921-x
dc.departamentoesGenética, antropología física y fisiología animales_ES
dc.departamentoeuGenetika,antropologia fisikoa eta animalien fisiologiaes_ES


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This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Cre-ative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not per-mitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Except where otherwise noted, this item's license is described as This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Cre-ative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not per-mitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.