Environmental factors modulated ancient mitochondrial DnA variability and the prevalence of rheumatic diseases in the Basque country
dc.contributor.author | Martín Laza, Imanol | |
dc.contributor.author | Hervella Afonso, Montserrat | |
dc.contributor.author | Neira Zubieta, Mikel | |
dc.contributor.author | De la Rúa Vaca, Concepción | |
dc.date.accessioned | 2020-02-17T13:11:00Z | |
dc.date.available | 2020-02-17T13:11:00Z | |
dc.date.issued | 2019-12-31 | |
dc.identifier.citation | Scientific Reports 9 : (2019) // Article ID 20380 | es_ES |
dc.identifier.issn | 2045-2322 | |
dc.identifier.uri | http://hdl.handle.net/10810/41148 | |
dc.description.abstract | Among the factors that would explain the distribution of mitochondrial lineages in Europe, climate and diseases may have played an important role. A possible explanation lies in the nature of the mitochondrion, in which the energy generation process produces reactive oxygen species that may influence the development of different diseases. The present study is focused on the medieval necropolis of San Miguel de Erenozar (13th-16th centuries, Basque Country), whose inhabitants presented a high prevalence of rheumatic diseases and lived during the Little Ice Age (LIA). Our results indicate a close relationship between rheumatic diseases and mitochondrial haplogroup H, and specifically between spondyloarthropathies and sub-haplogroup H2. One possible explanation may be the climate change that took place in the LIA that favoured those haplogroups that were more energy-efficient, such as haplogroup H, to endure lower temperatures and food shortage. However, it had a biological trade-off: the increased risk of developing rheumatic diseases. | es_ES |
dc.description.sponsorship | This work was supported by the Spanish Ministry of Economy, Industry and Competitiveness (GCL2016-79093/P), and grants from the Basque Government to Research Groups of the Basque University System (IT1138-16) and to Imanol Martin Laza (2014_1_326). We are grateful to the Institutions that granted permission for human remains study, including the Cultural Heritage Department of the Government of the Basque Country and the Archaeology Museum of Bizkaia. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Nature | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/GCL2016-79093/P | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | radiographic progression | es_ES |
dc.subject | degenerative diseases | es_ES |
dc.subject | haplogroups modulate | es_ES |
dc.subject | mtdna haplogroups; | es_ES |
dc.subject | osteoarthritis | es_ES |
dc.subject | metaanalysis | es_ES |
dc.subject | apoptosis | es_ES |
dc.subject | variants | es_ES |
dc.subject | risk | es_ES |
dc.subject | recolonization | es_ES |
dc.title | Environmental factors modulated ancient mitochondrial DnA variability and the prevalence of rheumatic diseases in the Basque country | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Cre-ative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not per-mitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. | es_ES |
dc.rights.holder | Atribución 3.0 España | * |
dc.relation.publisherversion | https://www.nature.com/articles/s41598-019-56921-x | es_ES |
dc.identifier.doi | 10.1038/s41598-019-56921-x | |
dc.departamentoes | Genética, antropología física y fisiología animal | es_ES |
dc.departamentoeu | Genetika,antropologia fisikoa eta animalien fisiologia | es_ES |
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