Contribution of the GABAergic System to Non-Motor Manifestations in Premotor and Early Stages of Parkinson’s Disease
dc.contributor.author | Murueta-Goyena Larrañaga, Ane | |
dc.contributor.author | Andikoetxea, Ane | |
dc.contributor.author | Gómez Esteban, Juan Carlos | |
dc.contributor.author | Gabilondo Cuellar, Iñigo | |
dc.date.accessioned | 2020-02-25T09:29:05Z | |
dc.date.available | 2020-02-25T09:29:05Z | |
dc.date.issued | 2019-10-30 | |
dc.identifier.citation | Frontiers in Pharmacology 10 : (2019) // Article ID 1294 | es_ES |
dc.identifier.issn | 1663-9812 | |
dc.identifier.uri | http://hdl.handle.net/10810/41432 | |
dc.description.abstract | Non-motor symptoms are common in Parkinson's disease (PD) and they represent a major source of disease burden. Several non-motor manifestations, such as rapid eye movement sleep behavior disorder, olfactory loss, gastrointestinal abnormalities, visual alterations, cognitive and mood disorders, are known to precede the onset of motor signs. Nonetheless, the mechanisms mediating these alterations are poorly understood and probably involve several neurotransmitter systems. The dysregulation of GABAergic system has received little attention in PD, although the spectrum of non-motor symptoms might be linked to this pathway. This Mini Review aims to provide up-to-date information about the involvement of the GABAergic system for explaining non-motor manifestations in early stages of PD. Therefore, special attention is paid to the clinical data derived from patients with isolated REM sleep behavior disorder or drug-naive patients with PD, as they represent prodromal and early stages of the disease, respectively. This, in combination with animal studies, might help us to understand how the disturbance of the GABAergic system is related to non-motor manifestations of PD. | es_ES |
dc.description.sponsorship | This study was partially funded by the Michael J. Fox Foundation (2014 Rapid Response Innovation Awards; Grant 10189), the Carlos III Health Institute through Projects PI14/00679 and PI16/00005, and a Juan Rodes Grant (JR15/00008) (I.G.) (cofunded by the "Investing in Your Future" European Regional Development Fund/European Social Fund programme), the Department of Health of the Basque Government through Project 2016111009, and EITB/BIOEF telemarathon for Neurodegenerative Diseases (BIO17/ND/010/BC). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Frontiers Media | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | GABA | es_ES |
dc.subject | REM sleep behavior disorder | es_ES |
dc.subject | hyposmia | es_ES |
dc.subject | visual alterations | es_ES |
dc.subject | gastrointestinal symptoms | es_ES |
dc.subject | neurotransmitters | es_ES |
dc.subject | sleep behavior disorder | es_ES |
dc.subject | messenger-rna expression | es_ES |
dc.subject | olfactory dysfunction | es_ES |
dc.subject | cognitive impairment | es_ES |
dc.subject | presynaptic inhibition | es_ES |
dc.subject | prefrontal cortex | es_ES |
dc.subject | basal ganglia | es_ES |
dc.subject | early marker | es_ES |
dc.subject | bulb | es_ES |
dc.title | Contribution of the GABAergic System to Non-Motor Manifestations in Premotor and Early Stages of Parkinson’s Disease | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | 2019 Murueta-Goyena, Andikoetxea, Gómez-Esteban and Gabilondo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | es_ES |
dc.rights.holder | Atribución 3.0 España | * |
dc.relation.publisherversion | https://www.frontiersin.org/articles/10.3389/fphar.2019.01294/full | es_ES |
dc.identifier.doi | 10.3389/fphar.2019.01294 | |
dc.departamentoes | Neurociencias | es_ES |
dc.departamentoeu | Neurozientziak | es_ES |
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Except where otherwise noted, this item's license is described as 2019 Murueta-Goyena, Andikoetxea, Gómez-Esteban and Gabilondo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.