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dc.contributor.authorSan Segundo Eizaguirre, Marcos
dc.contributor.authorCorrea Navarro, Arkaitz
dc.date.accessioned2020-02-25T09:29:57Z
dc.date.available2020-02-25T09:29:57Z
dc.date.issued2019-10-14
dc.identifier.citationChemical Science 10(38) : 8872-8879 (2019)es_ES
dc.identifier.issn2041-6520
dc.identifier.issn2041-6539
dc.identifier.urihttp://hdl.handle.net/10810/41433
dc.description.abstractThe site-selective functionalization of C-H bonds within a peptide framework remains a challenging task of prime synthetic importance. Herein, the first Pd-catalyzed delta-C(sp(2))-H acylation of Phe containing peptides with aldehydes is described. This oxidative coupling is distinguished by its site-specificity, tolerance of sensitive functional groups, scalability, and enantiospecificity and exhibits entire chemoselectivity for Phe motifs over other amino acid units. The compatibility of this dehydrogenative acylation platform with a number of oligopeptides of high structural complexity illustrates its ample opportunities for the late-stage peptide modification and bioconjugation.es_ES
dc.description.sponsorshipWe are grateful to MINECO (CTQ2016-78395-P; RTI2018093721-B-I00) and Basque Government (IT1033-16) for. nancial support. A.C. thanks MINECO for a Ramon y Cajal research contract (RYC-2012-09873). We acknowledge technical and human support provided by SGIker of UPV/EHU and European funding (ERDF and ESF). Cost-CHAOS action (CA15106) is also acknowledged.es_ES
dc.language.isoenges_ES
dc.publisherRoyal Society of Chemistryes_ES
dc.relationinfo:eu-repo/grantAgreement/MINECO/RYC-2012-09873es_ES
dc.relationinfo:eu-repo/grantAgreement/MINECO/CTQ2016-78395-Pes_ES
dc.relationinfo:eu-repo/grantAgreement/MINECO/RTI2018093721-B-I00es_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectC-H functionalizationes_ES
dc.subjectamino-acid derivativeses_ES
dc.subjectunactivated c(sp(3))-hes_ES
dc.subjectpalladiumes_ES
dc.subjectbondses_ES
dc.subjectdiversificationes_ES
dc.subjectactivationes_ES
dc.subjectarylationes_ES
dc.subjectolefinationes_ES
dc.subjectchemistryes_ES
dc.titlePd-catalyzed site-selective C(sp2)–H radical acylation of phenylalanine containing peptides with aldehydeses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.holderThis article is licensed under a Creative Commons Attribution 3.0 Unported Licence.es_ES
dc.rights.holderAtribución 3.0 España*
dc.relation.publisherversionhttps://pubs.rsc.org/en/content/articlelanding/2019/SC/C9SC03425K#!divAbstractes_ES
dc.identifier.doi10.1039/C9SC03425K
dc.departamentoesQuímica orgánica Ies_ES
dc.departamentoeuKimika organikoa Ies_ES


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