dc.contributor.author | Correia, João M. | |
dc.contributor.author | Caballero Gaudes, César | |
dc.contributor.author | Guediche, Sara | |
dc.contributor.author | Carreiras, Manuel | |
dc.date.accessioned | 2020-03-16T16:42:48Z | |
dc.date.available | 2020-03-16T16:42:48Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Correia, J.M., Caballero-Gaudes, C., Guediche, S. et al. Phonatory and articulatory representations of speech production in cortical and subcortical fMRI responses. Sci Rep 10, 4529 (2020). https://doi.org/10.1038/s41598-020-61435-y | es_ES |
dc.identifier.issn | 2045-2322 | |
dc.identifier.uri | http://hdl.handle.net/10810/42194 | |
dc.description | Published: 11 March 2020 | es_ES |
dc.description.abstract | Speaking involves coordination of multiple neuromotor systems, including respiration, phonation and articulation. Developing non-invasive imaging methods to study how the brain controls these systems is critical for understanding the neurobiology of speech production. Recent models and animal research suggest that regions beyond the primary motor cortex (M1) help orchestrate the neuromotor control needed for speaking, including cortical and sub-cortical regions. Using contrasts between speech conditions with controlled respiratory behavior, this fMRI study investigates articulatory gestures involving the tongue, lips and velum (i.e., alveolars versus bilabials, and nasals versus orals), and phonatory gestures (i.e., voiced versus whispered speech). Multivariate pattern analysis (MVPA) was used to decode articulatory gestures in M1, cerebellum and basal ganglia. Furthermore, apart from confirming the role of a mid-M1 region for phonation, we found that a dorsal M1 region, linked to respiratory control, showed significant differences for voiced compared to whispered speech despite matched lung volume observations. This region was also functionally connected to tongue and lip M1 seed regions, underlying its importance in the coordination of speech. Our study confirms and extends current knowledge regarding the neural mechanisms underlying neuromotor speech control, which hold promise to study neural dysfunctions involved in motor-speech disorders non-invasively. | es_ES |
dc.description.sponsorship | This work was supported by the Spanish Ministry of Economy and Competitiveness through the Juan de la Cierva Fellowship (FJCI-2015-26814), and the Ramon y Cajal Fellowship (RYC-2017- 21845), the Spanish State Research Agency through the BCBL “Severo Ochoa” excellence accreditation (SEV-2015-490), the Basque Government (BERC 2018- 2021) and the European Union’s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant (No 799554). We are grateful for the provision of simultaneous multi-slice (multiband) pulse sequence and reconstruction algorithms from the Center for Magnetic, Resonance Research (CMRR), University of Minnesota. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Scientific Reports | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/FJCI-2015-26814 | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/ RYC-2017-21845 | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/SEV-2015-0490 | es_ES |
dc.relation | info:eu-repo/grantAgreement/EC/H2020/MC/799554 | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Language | es_ES |
dc.subject | Motor cortex | es_ES |
dc.title | Phonatory and articulatory representations of speech production in cortical and subcortical fMRI responses | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. | es_ES |
dc.relation.publisherversion | https://www.nature.com/srep/ | es_ES |
dc.identifier.doi | 10.1038/s41598-020-61435-y | |