Show simple item record

dc.contributor.authorMeles, Sanne K.
dc.contributor.authorRenken, Remco J.
dc.contributor.authorPagani, Marco
dc.contributor.authorTeune, L.K.
dc.contributor.authorArnaldi, Dario
dc.contributor.authorMorbelli, Silvia
dc.contributor.authorNobili, Flavio
dc.contributor.authorVan Laar, Teus
dc.contributor.authorObeso, Jose A.
dc.contributor.authorRodríguez-Oroz, María C.
dc.contributor.authorLeenders, Klaus L.
dc.date.accessioned2020-03-18T09:53:33Z
dc.date.available2020-03-18T09:53:33Z
dc.date.issued2020
dc.identifier.citationMeles, S.K., Renken, R.J., Pagani, M. et al. Abnormal pattern of brain glucose metabolism in Parkinson’s disease: replication in three European cohorts. Eur J Nucl Med Mol Imaging 47, 437–450 (2020). https://doi.org/10.1007/s00259-019-04570-7es_ES
dc.identifier.issn1619-7070
dc.identifier.urihttp://hdl.handle.net/10810/42232
dc.descriptionPublished online: 25 November 2019es_ES
dc.description.abstractRationale In Parkinson’s disease (PD), spatial covariance analysis of 18F-FDG PET data has consistently revealed a characteristic PD-related brain pattern (PDRP). By quantifying PDRP expression on a scan-by-scan basis, this technique allows objective assessment of disease activity in individual subjects. We provide a further validation of the PDRP by applying spatial covariance analysis to PD cohorts from the Netherlands (NL), Italy (IT), and Spain (SP). Methods The PDRPNL was previously identified (17 controls, 19 PD) and its expression was determined in 19 healthy controls and 20 PD patients from the Netherlands. The PDRPIT was identified in 20 controls and 20 “de-novo” PD patients from an Italian cohort. A further 24 controls and 18 “de-novo” Italian patients were used for validation. The PDRPSP was identified in 19 controls and 19 PD patients from a Spanish cohort with late-stage PD. Thirty Spanish PD patients were used for validation. Patterns of the three centers were visually compared and then cross-validated. Furthermore, PDRP expression was determined in 8 patients with multiple system atrophy. Results A PDRP could be identified in each cohort. Each PDRP was characterized by relative hypermetabolism in the thalamus, putamen/pallidum, pons, cerebellum, and motor cortex. These changes co-varied with variable degrees of hypometabolism in posterior parietal, occipital, and frontal cortices. Frontal hypometabolism was less pronounced in “de-novo” PD subjects (Italian cohort). Occipital hypometabolism was more pronounced in late-stage PD subjects (Spanish cohort). PDRPIT, PDRPNL, and PDRPSP were significantly expressed in PD patients compared with controls in validation cohorts from the same center (P < 0.0001), and maintained significance on cross-validation (P < 0.005). PDRP expression was absent in MSA. Conclusion The PDRP is a reproducible disease characteristic across PD populations and scanning platforms globally. Further study is needed to identify the topography of specific PD subtypes, and to identify and correct for center-specific effects.es_ES
dc.description.sponsorshipThis study was funded in part by the Dutch “Stichting ParkinsonFonds.” The Navarra study was supported by grants from the Government of Navarra (32/2007), Spanish Institute of Health (ISCIII) PI08/1539, and CIBERNED, Spain.es_ES
dc.language.isoenges_ES
dc.publisherEuropean Journal of Nuclear Medicine and Molecular Imaginges_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subject18F-FDG PETes_ES
dc.subjectParkinson’s diseasees_ES
dc.subjectMetabolic patternes_ES
dc.subjectNetworkses_ES
dc.titleAbnormal pattern of brain glucose metabolism in Parkinson’s disease: replication in three European cohortses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.holder© The Author(s) 2019 Open Access This article is distributed under the terms of the Creative Commons At tribution 4.0 International License (http:/ / creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.es_ES
dc.relation.publisherversionhttps://www.springer.com/journal/259es_ES
dc.identifier.doi10.1007/s00259-019-04570-7


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record