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dc.contributor.authorSánchez Gutiérrez, Teresa
dc.contributor.authorFernandez Castilla, Belén
dc.contributor.authorBarbeito, Sara
dc.contributor.authorGonzález Pinto Arrillaga, Ana María
dc.contributor.authorBecerra García, Juan Antonio
dc.contributor.authorCalvo, Ana
dc.date.accessioned2020-04-15T10:41:50Z
dc.date.available2020-04-15T10:41:50Z
dc.date.issued2020-01-31
dc.identifier.citationEuropean psychiatry 63(1) : 1-10 (2020)es_ES
dc.identifier.issn1778-3585
dc.identifier.urihttp://hdl.handle.net/10810/42720
dc.description.abstractBACKGROUND.: The implications of cannabis use in the onset of early psychosis and the severity of psychotic symptoms have resulted in a proliferation of studies on this issue. However, few have examined the effects of cannabis use on the cognitive symptoms of psychosis (i.e., neurocognitive functioning) in patients with first-episode psychosis (FEP). This systematic review and meta-analysis aim to assess the neurocognitive functioning of cannabis users (CU) and nonusers (NU) with FEP. METHODS.: Of the 110 studies identified through the systematic review of 6 databases, 7 met the inclusion criteria, resulting in 14 independent samples and 78 effect sizes. The total sample included 304 CU with FEP and 369 NU with FEP. The moderator variables were age at first use, duration of use, percentage of males, and age. RESULTS.: Effect sizes were not significantly different from zero in any neurocognitive domain when users and NU were compared. Part of the variability in effect sizes was explained by the inclusion of the following moderator variables: (1) frequency of cannabis use (beta = 0.013, F = 7.56, p = 0.017); (2) first-generation antipsychotics (beta = 0.019, F = 34.46, p ≤ 0.001); and (3) country where the study was carried out (beta = 0.266, t = 2.06, p = 0.043). CONCLUSIONS.: This meta-analysis indicates that cannabis use is not generally associated with neurocognitive functioning in patients with FEP. However, it highlights the deleterious effect of low doses of cannabis in some patients. It also stresses the importance of the type of antipsychotic prescription and cannabis dose as moderator variables in the neurocognitive functioning of CU with FEP.es_ES
dc.description.sponsorshipThis study was partially funded by UNIR Research(http:// research.unir.net), Universidad Internacional de La Rioja (UNIR, http://www. unir.net), under Research Support Strategy 3 [2015–2017], Research Group “PSICONLINE General Health Psychology,” and the Ministry of Economy, Industry, and Competitiveness (MINECO) within the framework of the Subprogram Challenge-Research (Retos-Investigación) I+D+I 2017 (PSI2017- 82542-R).es_ES
dc.language.isoenges_ES
dc.publisherAssociation of European Psychiatristses_ES
dc.relationinfo:eu-repo/grantAgreement/MINECO/PSI2017- 82542-Res_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectcannabises_ES
dc.subjectfirst episodees_ES
dc.subjectmarihuanaes_ES
dc.subjectneurocognitiones_ES
dc.subjectpsychosises_ES
dc.titleCannabis use and nonuse in patients with first-episode psychosis: A systematic review and meta-analysis of studies comparing neurocognitive functioninges_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.holderThis is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.es_ES
dc.rights.holderAtribución 3.0 España*
dc.relation.publisherversionhttps://www.cambridge.org/core/journals/european-psychiatry/article/cannabis-use-and-nonuse-in-patients-with-firstepisode-psychosis-a-systematic-review-and-metaanalysis-of-studies-comparing-neurocognitive-functioning/38327E1B756BC34832D981DB5E84B3A8es_ES
dc.identifier.doi10.1192/j.eurpsy.2019.9
dc.departamentoesNeurocienciases_ES
dc.departamentoeuNeurozientziakes_ES


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This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Except where otherwise noted, this item's license is described as This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.