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dc.contributor.authorGaztañaga Echeverria, Mirari
dc.contributor.authorAngulo Alcalde, Asier
dc.contributor.authorChotro Lerda, María Gabriela
dc.date.accessioned2020-04-27T16:45:17Z
dc.date.available2020-04-27T16:45:17Z
dc.date.issued2020-03-05
dc.identifier.citationFrontiers in Behavioral Neuroscience 14 : (2020) // Article ID 26es_ES
dc.identifier.issn1662-5153
dc.identifier.urihttp://hdl.handle.net/10810/42916
dc.description.abstractPrenatal alcohol exposure has been found to be an important factor determining later consumption of this drug. In humans, despite the considerable diversity of variables that might influence alcohol consumption, longitudinal studies show that maternal alcohol intake during gestation is one of the best predictors of later alcohol use from adolescence to young adulthood. Experimental studies with animals also provide abundant evidence of the effects of prenatal alcohol exposure on later alcohol intake. In addition to increased consumption, other effects include enhanced palatability and attractiveness of alcohol flavor as well as sensitization to its sensory and reinforcing effects. Most of these outcomes have been obtained after exposing rats to binge-like administrations of moderate alcohol doses during the last gestational period when the fetus is already capable of detecting flavors in the amniotic fluid and learning associations with aversive or appetitive consequences. On this basis, it has been proposed that one of the mechanisms underlying the increased acceptance of alcohol after its prenatal exposure is the acquisition (by the fetus) of appetitive learning via an association between the sensory properties of alcohol and its reinforcing pharmacological effects. It also appears that this prenatal appetitive learning is mediated by the activation of the opioid system, with fetal brain acetaldehyde playing an important role, possibly as the main chemical responsible for its activation. Here, we review and analyze together the results of all animal studies testing these hypotheses through experimental manipulation of the behavioral and neurochemical elements of the assumed prenatal association. Understanding the mechanisms by which prenatal alcohol exposure favors the early initiation of alcohol consumption, along with its role in the causal pathway to alcohol disorders, may allow us to find strategies to mitigate the behavioral effects of this early experience with the drug. We propose that prenatal alcohol exposure is regarded as a case of involuntary early onset of alcohol use when designing prevention policies. This is particularly important, given the notion that the sooner alcohol intake begins, the greater the possibility of a continued history of alcohol consumption that may lead to the development of alcohol use disorders.es_ES
dc.description.sponsorshipThe research has been funded by the Basque Government (IT1341-19) to the research group (PI: Gabriel Rodriguez San Juan).es_ES
dc.language.isoenges_ES
dc.publisherFrontiers Mediaes_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectprenatales_ES
dc.subjectalcoholes_ES
dc.subjectlearninges_ES
dc.subjectopioidses_ES
dc.subjectacetaldehydees_ES
dc.subjectassociativees_ES
dc.subjectreinforceres_ES
dc.subjectgestational ethanol exposurees_ES
dc.subjectendogenous opioid systemes_ES
dc.subjectsleep-wake behaviores_ES
dc.subjectspectrum disorderses_ES
dc.subjectfetal-ethanoles_ES
dc.subjectrat fetuses_ES
dc.subjectmaternal consumptiones_ES
dc.subjectfamily-historyes_ES
dc.subjectbinge ethanoles_ES
dc.subjectpregnant ratses_ES
dc.titlePrenatal Alcohol Exposure as a Case of Involuntary Early Onset of Alcohol Use: Consequences and Proposed Mechanisms From Animal Studieses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.holder2020 Gaztañaga, Angulo-Alcalde and Chotro. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.es_ES
dc.rights.holderAtribución 3.0 España*
dc.relation.publisherversionhttps://www.frontiersin.org/articles/10.3389/fnbeh.2020.00026/fulles_ES
dc.identifier.doi10.3389/fnbeh.2020.00026
dc.departamentoesProcesos psicológicos básicos y su desarrolloes_ES
dc.departamentoeuOinarrizko psikologia prozesuak eta haien garapenaes_ES


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2020 Gaztañaga, Angulo-Alcalde and Chotro. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Except where otherwise noted, this item's license is described as 2020 Gaztañaga, Angulo-Alcalde and Chotro. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.