Increased Th17-Related Cytokine Serum Levels in Patients With Multiple Polyps of Unexplained Origin
dc.contributor.author | Alustiza, Miren | |
dc.contributor.author | Hernández Illán, Eva | |
dc.contributor.author | Juárez, Miriam | |
dc.contributor.author | Giner Calabuig, Mar | |
dc.contributor.author | Mira, Cristina | |
dc.contributor.author | Martínez Roca, Alejandro | |
dc.contributor.author | Bujanda Fernández de Pierola, Luis | |
dc.contributor.author | Rodríguez Moranta, Francisco | |
dc.contributor.author | Cubiella, Joaquín | |
dc.contributor.author | De Castro, Luisa | |
dc.contributor.author | Marín Gabriel, José Carlos | |
dc.contributor.author | Herreros de Tejada, Alberto | |
dc.contributor.author | Fernández Bañares, Fernando | |
dc.contributor.author | Nicolás Pérez, David | |
dc.contributor.author | Giménez, Paula | |
dc.contributor.author | Martínez Cardona, Claudia | |
dc.contributor.author | Francés, Rubén | |
dc.contributor.author | Murcia, Oscar | |
dc.contributor.author | Jover, Rodrigo | |
dc.date.accessioned | 2020-05-06T10:30:57Z | |
dc.date.available | 2020-05-06T10:30:57Z | |
dc.date.issued | 2020-03 | |
dc.identifier.citation | Clinical and translational gastroenterology 11(3) : (2020) // Article ID e00143 | es_ES |
dc.identifier.issn | 2155-384X | |
dc.identifier.uri | http://hdl.handle.net/10810/43034 | |
dc.description.abstract | OBJECTIVES: Most patients with multiple colonic polyps do not have a known genetic or hereditary origin. Our aim was to analyze the presence of inflammatory cytokines and levels of glucose, insulin, and C-reactive protein (CRP) in patients with multiple colonic polyps. METHODS: Eighty-three patients with 10 or more adenomatous or serrated polyps and 53 control people with normal colonoscopy were included. Smoking habits were registered, and glucose, CRP, and basal insulin in the serum/blood were measured. Quantification of IL-2, IL-4, IL-6, IL-10, IL-11, IL-17A, and IL-23 cytokine levels in the serum was performed by a high-sensitivity enzyme-linked immunosorbent assay. RESULTS: Smoking and diabetes were more prevalent in those with colonic polyps than in the control people (67% vs 16%, P = 0.001; 11% vs 2%, P = 0.048). In addition, the cytokine serum levels were higher, i.e., IL-2 (P = 0.001), IL-4 (P = 0.001), IL-6 (P = 0.001), IL-17A (P = 0.001), IL-23 (P = 0.014), and CRP (P = 0.003). Adjusting for sex, smoking, and diabetes in a multivariate analysis, IL-2, IL-4, IL-6, IL-17A, and IL-23 remained independently elevated in cases with multiple polyps. DISCUSSION: These results indicate that immune responses mediated by Th17 cells may be involved in the pathogenesis of multiple colonic polyps. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Wolters Kluwer | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | * |
dc.title | Increased Th17-Related Cytokine Serum Levels in Patients With Multiple Polyps of Unexplained Origin | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal | es_ES |
dc.rights.holder | Atribución-NoComercial-SinDerivadas 3.0 España | * |
dc.relation.publisherversion | https://journals.lww.com/ctg/FullText/2020/03000/Increased_Th17_Related_Cytokine_Serum_Levels_in.11.aspx | es_ES |
dc.identifier.doi | 10.14309/ctg.0000000000000143 | |
dc.departamentoes | Medicina | es_ES |
dc.departamentoeu | Medikuntza | es_ES |
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