Encapsulation of Oleuropein in Nanostructured Lipid Carriers: Biocompatibility and Antioxidant Efficacy in Lung Epithelial Cells
dc.contributor.author | Huguet Casquero, Amaia | |
dc.contributor.author | Moreno Sastre, María | |
dc.contributor.author | López Méndez, Tania Belén | |
dc.contributor.author | Gainza Lafuente, Eusebio | |
dc.contributor.author | Pedraz Muñoz, José Luis | |
dc.date.accessioned | 2020-05-31T21:18:19Z | |
dc.date.available | 2020-05-31T21:18:19Z | |
dc.date.issued | 2020-05-06 | |
dc.identifier.citation | Pharmaceutics 12(5) : (2020) // Article ID 429 | es_ES |
dc.identifier.issn | 1999-4923 | |
dc.identifier.uri | http://hdl.handle.net/10810/43637 | |
dc.description.abstract | Oxidative damage has been linked to a number of diseases. Oleuropein (OLE), a natural occurring polyphenol from olive leaves (Olea europaea L.), is known to be a potent antioxidant compound with inherent instability and compromised bioavailability. Therefore, in this work, nanostructured lipid carriers (NLCs) were proposed for OLE encapsulation to protect and improve its antioxidant efficacy. The lipid matrix, composed of olive oil and Precirol, was optimized prior to OLE encapsulation. The characterization of the optimized oleuropein-loaded NLCs (NLC-OLE) showed a mean size of 150 nm, a zeta potential of −21 mV, an encapsulation efficiency of 99.12%, sustained release profile, and improved radical scavenging activity. The cellular in vitro assays demonstrated the biocompatibility of the NLCs, which were found to improve and maintain OLE antioxidant efficacy in the A549 and CuFi-1 lung epithelial cell lines, respectively. Overall, these findings suggest a promising potential of NLC-OLE to further design a pulmonary formulation for OLE delivery in lung epithelia. | es_ES |
dc.description.sponsorship | A.H.-C. thanks the Spanish Ministry of Economy and Competitiveness for the Industrial Doctorate fellowship grant (DI-15-07513). This work was done under the R&D projects of BIOSASUN and supported by the University of the Basque Country (UPV/EHU) and the Basque Country Government (Grupos Consolidados, No. IT907-16 to J.L.P.). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/DI-15-07513 | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | |
dc.subject | oleuropein | es_ES |
dc.subject | polyphenols | es_ES |
dc.subject | nanoparticle | es_ES |
dc.subject | natural antioxidant | es_ES |
dc.subject | nanotechnology | es_ES |
dc.subject | olive oil | es_ES |
dc.title | Encapsulation of Oleuropein in Nanostructured Lipid Carriers: Biocompatibility and Antioxidant Efficacy in Lung Epithelial Cells | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.date.updated | 2020-05-28T14:09:30Z | |
dc.rights.holder | 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | es_ES |
dc.relation.publisherversion | https://www.mdpi.com/1999-4923/12/5/429/htm | es_ES |
dc.identifier.doi | 10.3390/pharmaceutics12050429 | |
dc.departamentoes | Farmacia y ciencias de los alimentos | |
dc.departamentoeu | Farmazia eta elikagaien zientziak |
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Except where otherwise noted, this item's license is described as 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).