dc.contributor.author | De Tito, Stefano | |
dc.contributor.author | Hervás Hidalgo, Javier ![ORCID](/themes/Mirage2//images/orcid_16x16.png) | |
dc.contributor.author | Van Vliet, Alexander R. | |
dc.contributor.author | Tooze, Sharon A. | |
dc.date.accessioned | 2020-06-03T08:13:16Z | |
dc.date.available | 2020-06-03T08:13:16Z | |
dc.date.issued | 2020-06 | |
dc.identifier.citation | Trends in biochemical sciences 45(6) : 484-496 (2020) | es_ES |
dc.identifier.issn | 0968-0004 | |
dc.identifier.uri | http://hdl.handle.net/10810/43739 | |
dc.description.abstract | Autophagy is traditionally depicted as a signaling cascade that culminates in the formation of an autophagosome that degrades cellular cargo. However, recent studies have identified myriad pathways and cellular organelles underlying the autophagy process, be it as signaling platforms or through the contribution of proteins and lipids. The Golgi complex is recognized as being a central transport hub in the cell, with a critical role in endocytic trafficking and endoplasmic reticulum (ER) to plasma membrane (PM) transport. However, the Golgi is also an important site of key autophagy regulators, including the protein autophagy-related (ATG)-9A and the lipid, phosphatidylinositol-4-phosphate [PI(4)P]. In this review, we highlight the central function of this organelle in autophagy as a transport hub supplying various components of autophagosome formation. | es_ES |
dc.description.sponsorship | This project has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 re- search and innovation programme (grant agreement No 788708) and the Francis Crick Institute, which receives its core funding from Cancer Research UK (FC001187); the UK Medical Research Council (FC001187); and the Welcome Trust (FC001187). A.R.vV. was supported by an EMBO long-term fellowship (EMBO ALTF 325-2017). J.H.H. was supported by a Postdoctoral Fellowship from the Basque Government. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.relation | info:eu-repo/grantAgreement/EC/H2020/788708 | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | ATG9A | es_ES |
dc.subject | BAR domain | es_ES |
dc.subject | Golgi complex | es_ES |
dc.subject | PI(4)P | es_ES |
dc.subject | adaptor complexes | es_ES |
dc.subject | autophagy | es_ES |
dc.title | The Golgi as an Assembly Line to the Autophagosome | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | 2020 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0 | es_ES |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S0968000420300876?via%3Dihub | es_ES |
dc.identifier.doi | 10.1016/j.tibs.2020.03.010 | |
dc.contributor.funder | European Commission | |
dc.departamentoes | Bioquímica y biología molecular | es_ES |
dc.departamentoeu | Biokimika eta biologia molekularra | es_ES |