An Overground Robotic Gait Training Program for People With Multiple Sclerosis: A Protocol for a Randomized Clinical Trial
dc.contributor.author | Berriozabalgoitia, Rakel | |
dc.contributor.author | Sanz Echevarría, María Begoña | |
dc.contributor.author | Fraile Bermúdez, Ana Belén | |
dc.contributor.author | Otxoa, Erika | |
dc.contributor.author | Yeregui Prieto, Izaskun | |
dc.contributor.author | Bidaurrazaga López de Letona, Iraia | |
dc.contributor.author | Duñabeitia Usategui, Iratxe | |
dc.contributor.author | Rodríguez-Antigüedad Zarranz, Alfredo | |
dc.contributor.author | Domercq García, María | |
dc.contributor.author | Irazusta Astiazaran, Jon | |
dc.contributor.author | Rodríguez Larrad, Ana | |
dc.date.accessioned | 2020-06-30T12:13:24Z | |
dc.date.available | 2020-06-30T12:13:24Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Frontiers in Medicine 7 : (2020) // Article ID 238 | es_ES |
dc.identifier.issn | 2296-858X | |
dc.identifier.uri | http://hdl.handle.net/10810/44762 | |
dc.description.abstract | Maintaining the ability to walk is one of the significant challenges in people with multiple sclerosis (MS) for keeping a good quality of life as the disease and the aging process progresses. Overground robotic (OR) wearable exoskeletons are promising tools for gait rehabilitation, but currently there is no evidence of their clinical effects on patients with MS. The present study aims to determine the effects of an OR intervention in people with MS and moderate to severe walking disabilities and ascertain if benefits are maintained over a follow-up period of 3 months. This randomized controlled trial will include 36 participants with MS. Inclusion criteria are: older than 18 years, definitive diagnosis of MS, 4.5-7 points on the EDSS (Expanded Disability Status Scale), and needing one or two canes or crutches for walking outdoors. Subjects in the control group will receive conventional physiotherapy sessions at ADEMBI (Asociacion de Esclerosis Multiple de Bizkaia) provided to control spasticity, maintain articular range and exercise balance. Subjects in the intervention group will receive the same physiotherapy but also participate in a progressive OR gait training program assisted by the EksoTM exoskeleton. The program consists of twice a week individually supervised sessions in two setting modalities: PreGait and ProStepPlus. The training parameters (duration, speed, cadence, length of steps) will be set during the first session and the progression and intensity of the intervention will be adapted to the tolerance of each participant. The primary outcome of this study is gait speed. Secondary outcomes will include physical and cognitive performance tests, clinical, fatigue and quality of life assessments, and changes in the plasma levels of inflammatory cytokines. The present trial is the first analyzing the effectiveness of an OR intervention for gait training in patients with MS. It will help clarify the applicability of robotic technologies to clinical practice, extending the functionality and quality of life of people with MS to face a successful aging process. (ACTRN12619000014156; https://anzctr.org.au/Trial/Registration/TrialReview.aspx?id=376548). | es_ES |
dc.description.sponsorship | This research was partially supported by Bilbao Bizkaia Kutxa Bank Foundation, Euskampus Fundazioa Foundation and by the Ministry of Science of Spain under Grant No. DPI2017-82694-R (AEI/FEDER, UE). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Frontiers Media | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | exoskeleton | es_ES |
dc.subject | gait speed | es_ES |
dc.subject | inflammation biomarkers | es_ES |
dc.subject | multiple sclerosis | es_ES |
dc.subject | quality of life | es_ES |
dc.subject | rehabilitation | es_ES |
dc.title | An Overground Robotic Gait Training Program for People With Multiple Sclerosis: A Protocol for a Randomized Clinical Trial | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | 2020 Berriozabalgoitia, Sanz, Fraile-Bermúdez, Otxoa, Yeregui, Bidaurrazaga-Letona, Duñabeitia, Antigüedad, Domercq, Irazusta and Rodriguez-Larrad. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | es_ES |
dc.rights.holder | Atribución 3.0 España | * |
dc.relation.publisherversion | https://www.frontiersin.org/articles/10.3389/fmed.2020.00238/full | es_ES |
dc.identifier.doi | 10.3389/fmed.2020.00238 | |
dc.departamentoes | Enfermería | es_ES |
dc.departamentoes | Fisiología | es_ES |
dc.departamentoes | Neurociencias | es_ES |
dc.departamentoeu | Erizaintza | es_ES |
dc.departamentoeu | Fisiologia | es_ES |
dc.departamentoeu | Neurozientziak | es_ES |
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Except where otherwise noted, this item's license is described as 2020 Berriozabalgoitia, Sanz, Fraile-Bermúdez, Otxoa, Yeregui, Bidaurrazaga-Letona, Duñabeitia, Antigüedad, Domercq, Irazusta and Rodriguez-Larrad. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.