Cholesterol and Alzheimer’s Disease Risk: A Meta-Meta-Analysis
dc.contributor.author | Sáiz Vázquez, Olalla | |
dc.contributor.author | Puente Martínez, Alicia | |
dc.contributor.author | Ubillos Landa, Silvia | |
dc.contributor.author | Pacheco Bonrostro, Joaquín | |
dc.contributor.author | Santabárbara, Javier | |
dc.date.accessioned | 2020-07-02T09:09:24Z | |
dc.date.available | 2020-07-02T09:09:24Z | |
dc.date.issued | 2020-06-18 | |
dc.identifier.citation | Brain Sciences 10(6) : (2020) // Article ID 386 | es_ES |
dc.identifier.issn | 2076-3425 | |
dc.identifier.uri | http://hdl.handle.net/10810/44807 | |
dc.description.abstract | Background: Alzheimer’s disease (AD) is the most common subtype of dementia. In the last ten years, the relationship between cholesterol and AD has been investigated. Evidence suggests that cholesterol is associated with AD and represents promising targets for intervention. However, the causality of these associations is unclear. Therefore, we sought to conduct a meta-meta-analysis to determine the effect of cholesterol on the development AD. Then, we assessed the effect of serum levels of low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C), total cholesterol (TC) and triglycerides (TG), on AD risk. Methods: A systematic search of meta-analyses was conducted. Scopus, Web of Science, Science direct, PubMed and Google academic system databases were reviewed. Results: We found 100 primary studies and five meta-analyses to analyze the relationships between cholesterol and AD. The total effect of cholesterol on risk of AD was significant and heterogeneous. Subgroup analysis shows that LDL-C levels influence the development of AD. However, non-significant effects of HDL-C, TC and TG levels on AD were found. Conclusions: These results strengthen the evidence that LDL-C cholesterol levels increase risk for AD. More initiatives to investigate the relationship between cholesterol and AD are needed. | es_ES |
dc.description.sponsorship | This research was funded by a research grant from the Basque Country, Spain (awarded to A.P.), by the Junta of Castilla y León (Spain) to the Social Inclusion and Quality of Life (SIQoL) (No.665501), by FEDER funds and the Spanish Ministry of Economy and Competitiveness (Projects ECO2013-47129-C4-3-R and ECO2016-76567-C4-2-R), by the Regional Government of Castilla y León and FEDER funds (Projects BU329U14, BU071G19 and BU062U16), and by the Fondo de Investigación Sanitaria, Instituto de Salud Carlos III, Spanish Ministry of Economy and Competitiveness, Madrid, Spain (grants 94/1562, 97/1321E, 98/0103, 01/0255, 03/0815, 06/0617, G03/128, 19/01874). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/ECO2013-47129-C4-3-R | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/ECO2016-76567-C4-2-R | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | |
dc.subject | Alzheimer’s disease | es_ES |
dc.subject | etiology | es_ES |
dc.subject | cholesterol | es_ES |
dc.subject | risk factors | es_ES |
dc.subject | meta-analysis | es_ES |
dc.title | Cholesterol and Alzheimer’s Disease Risk: A Meta-Meta-Analysis | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.date.updated | 2020-06-30T16:26:37Z | |
dc.rights.holder | 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | es_ES |
dc.relation.publisherversion | https://www.mdpi.com/2076-3425/10/6/386/htm | es_ES |
dc.identifier.doi | 10.3390/brainsci10060386 | |
dc.departamentoes | Psicología Social y Metodología de las Ciencias del Comportamiento | |
dc.departamentoeu | Gizarte psikologia eta portaera zientzen metodologia |
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Except where otherwise noted, this item's license is described as 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).