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dc.contributor.authorGonzález-Pardo, Héctor
dc.contributor.authorArias, Jorge L.
dc.contributor.authorGómez Lázaro, Eneritz
dc.contributor.authorLópez Taboada, Isabel
dc.contributor.authorConejo, Nélida M.
dc.date.accessioned2020-07-30T10:57:42Z
dc.date.available2020-07-30T10:57:42Z
dc.date.issued2020-07-14
dc.identifier.citationBrain Sciences 10(7) : (2020) // Article ID 447es_ES
dc.identifier.issn2076-3425
dc.identifier.urihttp://hdl.handle.net/10810/45801
dc.description.abstractSex differences have been reported in the susceptibility to early life stress and its neurobiological correlates in humans and experimental animals. However, most of the current research with animal models of early stress has been performed mainly in males. In the present study, prolonged maternal separation (MS) paradigm was applied as an animal model to resemble the effects of adverse early experiences in male and female rats. Regional brain mitochondrial function, monoaminergic activity, and neuroinflammation were evaluated as adults. Mitochondrial energy metabolism was greatly decreased in MS females as compared with MS males in the prefrontal cortex, dorsal hippocampus, and the nucleus accumbens shell. In addition, MS males had lower serotonin levels and increased serotonin turnover in the prefrontal cortex and the hippocampus. However, MS females showed increased dopamine turnover in the prefrontal cortex and increased norepinephrine turnover in the striatum, but decreased dopamine turnover in the hippocampus. Sex differences were also found for pro-inflammatory cytokine levels, with increased levels of TNF-α and IL-6 in the prefrontal cortex and hippocampus of MS males, and increased IL-6 levels in the striatum of MS females. These results evidence the complex sex- and brain region-specific long-term consequences of early life stress.es_ES
dc.description.sponsorshipThis work was supported by grants PSI 2017-83038-P to HGP and NC, PSI 2017-90806-REDT to JLA, PSI 2017-83893-R to JLA (Ministry of Economy and Competitiveness, Spain).es_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.relationinfo:eu-repo/grantAgreement/MINECO/PSI-2017-83038-Pes_ES
dc.relationinfo:eu-repo/grantAgreement/MINECO/PSI-2017-90806-REDTes_ES
dc.relationInfo:eu-repo/grantAgreement/MINECO/PSI-2017-83893-Res_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/
dc.subjectmaternal separationes_ES
dc.subjectsexes_ES
dc.subjectcytochrome oxidasees_ES
dc.subjectcytokinees_ES
dc.subjectmonoaminees_ES
dc.subjectprefrontal cortexes_ES
dc.subjecthippocampuses_ES
dc.subjectstriatumes_ES
dc.titleSex-Specific Effects of Early Life Stress on Brain Mitochondrial Function, Monoamine Levels and Neuroinflammationes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.date.updated2020-07-24T13:36:59Z
dc.rights.holder© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).es_ES
dc.relation.publisherversionhttps://www.mdpi.com/2076-3425/10/7/447es_ES
dc.identifier.doi10.3390/brainsci10070447
dc.departamentoesProcesos psicológicos básicos y su desarrollo
dc.departamentoeuOinarrizko psikologia prozesuak eta haien garapena


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© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Except where otherwise noted, this item's license is described as © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).