Brain White Matter Correlates of Creativity in Schizophrenia: A Diffusion Tensor Imaging Study
dc.contributor.author | Sampedro, Agurne | |
dc.contributor.author | Peña Lasa, Javier | |
dc.contributor.author | Ibarretxe Bilbao, Naroa | |
dc.contributor.author | Cabrera Zubizarreta, Alberto | |
dc.contributor.author | Sánchez Gómez, Pedro María | |
dc.contributor.author | Gómez Gastiasoro, Ainara | |
dc.contributor.author | Iriarte Yoller, Nagore | |
dc.contributor.author | Pavón, Cristóbal | |
dc.contributor.author | Ojeda, Natalia | |
dc.date.accessioned | 2020-10-23T12:21:39Z | |
dc.date.available | 2020-10-23T12:21:39Z | |
dc.date.issued | 2020-06 | |
dc.identifier.citation | Frontiers in Neurosciences 14 : (2020) // Article ID 572 | es_ES |
dc.identifier.issn | 1662-453X | |
dc.identifier.uri | http://hdl.handle.net/10810/47266 | |
dc.description.abstract | The relationship between creativity and psychopathology has been a controversial research topic for decades. Specifically, it has been shown that people with schizophrenia have an impairment in creative performance. However, little is known about the brain correlates underlying this impairment. Therefore, the aim of this study was to analyze whole brain white matter (WM) correlates of several creativity dimensions in people with schizophrenia. Fifty-five patients with schizophrenia underwent diffusion-weighted imaging on a 3T magnetic resonance imaging machine as well as a clinical and a creativity assessment, including verbal and figural creativity measures. Tract-based spatial statistic, implemented in FMRIB Software Library (FSL), was used to assess whole brain WM correlates with different creativity dimensions, controlling for sex, age, premorbid IQ, and medication. Mean fractional anisotropy (FA) in frontal, temporal, subcortical, brain stem, and interhemispheric regions correlated positively with figural originality. The most significant clusters included the right corticospinal tract (cerebral peduncle part) and the right body of the corpus callosum. Verbal creativity did not show any significant correlation. As a whole, these findings suggest that widespread WM integrity is involved in creative performance of patients with schizophrenia. Many of these areas have also been related to creativity in healthy people. In addition, some of these regions have shown to be particularly impaired in schizophrenia, suggesting that these WM alterations could be underlying the worse creative performance found in this pathology. | es_ES |
dc.description.sponsorship | This study has been supported by the Spanish Ministry of Economy and Competitiveness (PI16/01022) and the Department of Education and Science of the Basque Government (Team A) (IT946-16). AS was supported by a fellowship from the Fundacion Tatiana Perez de Guzman el Bueno. AG-G was supported by a fellowship from the Education, Language, Politics and Culture Department of the Basque Government (PRE_2015_1_0444). The funding agencies had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Frontiers Media | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/PI16/01022 | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | creativity | es_ES |
dc.subject | schizophrenia | es_ES |
dc.subject | white matter | es_ES |
dc.subject | divergent thinking | es_ES |
dc.subject | psychosis | es_ES |
dc.subject | fractional anisotropy | es_ES |
dc.subject | orbitofrontal cortex | es_ES |
dc.subject | connectivity analysis | es_ES |
dc.subject | dose equivalents | es_ES |
dc.subject | working-memory | es_ES |
dc.subject | intelligence | es_ES |
dc.subject | thinking | es_ES |
dc.subject | abnormalities | es_ES |
dc.subject | network | es_ES |
dc.subject | divergent | es_ES |
dc.subject | integrity | es_ES |
dc.title | Brain White Matter Correlates of Creativity in Schizophrenia: A Diffusion Tensor Imaging Study | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | 2020 Sampedro, Peña, Ibarretxe-Bilbao, Cabrera-Zubizarreta, Sánchez, Gómez-Gastiasoro, Iriarte-Yoller, Pavón and Ojeda. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | es_ES |
dc.rights.holder | Atribución 3.0 España | * |
dc.relation.publisherversion | https://www.frontiersin.org/articles/10.3389/fnins.2020.00572/full | es_ES |
dc.identifier.doi | 10.3389/fnins.2020.00572 | |
dc.departamentoes | Neurociencias | es_ES |
dc.departamentoeu | Neurozientziak | es_ES |
Files in this item
This item appears in the following Collection(s)
Except where otherwise noted, this item's license is described as 2020 Sampedro, Peña, Ibarretxe-Bilbao, Cabrera-Zubizarreta, Sánchez, Gómez-Gastiasoro, Iriarte-Yoller, Pavón and Ojeda. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.