Postweaning Grouping as a Strategy to Reduce Singly Housed Male Mice
dc.contributor.author | Grífols, Roger | |
dc.contributor.author | Zamora, Carolina | |
dc.contributor.author | Ortega Sáez, Iván | |
dc.contributor.author | Azkona Mendoza, Garikoitz ![]() | |
dc.date.accessioned | 2020-11-30T09:32:59Z | |
dc.date.available | 2020-11-30T09:32:59Z | |
dc.date.issued | 2020-11-17 | |
dc.identifier.citation | Animals 10(11) : (2020) // Article ID 2135 | es_ES |
dc.identifier.issn | 2076-2615 | |
dc.identifier.uri | http://hdl.handle.net/10810/48707 | |
dc.description.abstract | Rearing laboratory mice in groups is important since social isolation after weaning induces brain alterations, which entails behavioral abnormalities in adulthood. Age is an important factor when grouping males of different litters due to inter-male aggressiveness. The aim of this study was to determine whether newly weaned mice could safely be grouped with late juvenile or early and late pubescent mice, and whether cage cleaning, the number of the hosting group members and testosterone plasma levels have any influence. Newly weaned C57BL/6J, CD1, and SCID Beige male mice were systematically grouped with same strain late juvenile, early or late pubescent male mice in clean or dirty cages of 1, 2 or 3 hosting members. We also analyzed plasma testosterone levels at different postnatal days. Our result showed that only strain and hosting male’s age influence agonistic behavior toward newly weaned mice. Thus, in order not to house a recently weaned male alone, we would recommend grouping it with late juvenile same strain mice in all studied strains. In the same way, CD1 and SCID Beige pubescent mice will admit a newly weaned mouse in their group. However, we would not recommend grouping newly weaned and pubescent C57BL/6J males. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | |
dc.subject | juvenile | es_ES |
dc.subject | pubescent | es_ES |
dc.subject | aggressiveness | es_ES |
dc.subject | testosterone | es_ES |
dc.subject | mouse | es_ES |
dc.title | Postweaning Grouping as a Strategy to Reduce Singly Housed Male Mice | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.date.updated | 2020-11-26T14:07:59Z | |
dc.rights.holder | 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | es_ES |
dc.relation.publisherversion | https://www.mdpi.com/2076-2615/10/11/2135/htm | es_ES |
dc.identifier.doi | 10.3390/ani10112135 | |
dc.departamentoes | Procesos psicológicos básicos y su desarrollo | |
dc.departamentoeu | Oinarrizko psikologia prozesuak eta haien garapena |
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Except where otherwise noted, this item's license is described as 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).